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Involvement of UTR-dependent gene expression in the maintenance of cancer stem cell like phenotypes.
Title: | Involvement of UTR-dependent gene expression in the maintenance of cancer stem cell like phenotypes. |
Authors: | Yasuda, Motoaki Browse this author →KAKEN DB | Hatanaka, Tomoyuki Browse this author | Shirato, Hiroki Browse this author →KAKEN DB | Nishioka, Takeshi Browse this author |
Keywords: | hypoxia-inducible factor-1 alpha | Ets2 | c-fos | repopulation | radio-resistance | untranslated region | cancer stem cell |
Issue Date: | Nov-2015 |
Publisher: | Spandidos Publications |
Journal Title: | Oncology letters |
Volume: | 10 |
Issue: | 5 |
Start Page: | 3171 |
End Page: | 3176 |
Publisher DOI: | 10.3892/ol.2015.3688 |
PMID: | 26722307 |
Abstract: | The present study demonstrated the acquisition of additional malignant characteristics in irradiated mouse fibrosarcoma cells compared with the parent cells. Several reporter assays indicated that hypoxia-inducible factor (HIF)-1 alpha, activator protein-1 and Ets-dependent transcription were activated in irradiated cells. The cis-elements in the 5'-untranslated region (UTR) of these transcription factors plays a major role in their expression in surviving irradiated cancer cells. By contrast, there were no evident differences between the 3'-UTR-dependent repression demonstrated by parent cells and irradiated cells. A small population of parental fibrosarcoma cells was also found to exhibit the same enhanced 5'-UTR-dependent HIF-1 alpha expression as that demonstrated by irradiated cells. These observations may indicate that high-dose X-ray irradiation affects the majority of proliferating cancer cells, but not the cancer stem cells (CSCs), and an increased CSC population may explain the progressive phenotypes of the irradiated cells. It appears likely that the transcription factors that maintain stemness are regulated by the same 5'-UTR-dependent mechanism. |
Type: | article |
URI: | http://hdl.handle.net/2115/60820 |
Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc) 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 安田 元昭
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