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Involvement of UTR-dependent gene expression in the maintenance of cancer stem cell like phenotypes.

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Title: Involvement of UTR-dependent gene expression in the maintenance of cancer stem cell like phenotypes.
Authors: Yasuda, Motoaki Browse this author →KAKEN DB
Hatanaka, Tomoyuki Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Nishioka, Takeshi Browse this author
Keywords: hypoxia-inducible factor-1 alpha
untranslated region
cancer stem cell
Issue Date: Nov-2015
Publisher: Spandidos Publications
Journal Title: Oncology letters
Volume: 10
Issue: 5
Start Page: 3171
End Page: 3176
Publisher DOI: 10.3892/ol.2015.3688
PMID: 26722307
Abstract: The present study demonstrated the acquisition of additional malignant characteristics in irradiated mouse fibrosarcoma cells compared with the parent cells. Several reporter assays indicated that hypoxia-inducible factor (HIF)-1 alpha, activator protein-1 and Ets-dependent transcription were activated in irradiated cells. The cis-elements in the 5'-untranslated region (UTR) of these transcription factors plays a major role in their expression in surviving irradiated cancer cells. By contrast, there were no evident differences between the 3'-UTR-dependent repression demonstrated by parent cells and irradiated cells. A small population of parental fibrosarcoma cells was also found to exhibit the same enhanced 5'-UTR-dependent HIF-1 alpha expression as that demonstrated by irradiated cells. These observations may indicate that high-dose X-ray irradiation affects the majority of proliferating cancer cells, but not the cancer stem cells (CSCs), and an increased CSC population may explain the progressive phenotypes of the irradiated cells. It appears likely that the transcription factors that maintain stemness are regulated by the same 5'-UTR-dependent mechanism.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 安田 元昭

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