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Three-dimensional conformal fractionated radiotherapy for spinal schwannoma with a paravertebral or an intraosseous component

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Title: Three-dimensional conformal fractionated radiotherapy for spinal schwannoma with a paravertebral or an intraosseous component
Authors: Onimaru, Rikiya Browse this author →KAKEN DB
Hida, Kazutoshi Browse this author →KAKEN DB
Takeda, Naoki Browse this author →KAKEN DB
Onodera, Shunsuke Browse this author
Nishikawa, Yukiko Browse this author
Mori, Takashi Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Spinal schwannoma
Paravertebral schwannoma
Three-dimensional conformal radiotherapy (3D-CRT)
Fractionated radiotherapy
Conventional fractionation
Issue Date: Dec-2015
Publisher: Springer
Japan Radiological Society
Journal Title: Japanese journal of radiology
Volume: 33
Issue: 12
Start Page: 757
End Page: 763
Publisher DOI: 10.1007/s11604-015-0492-4
PMID: 26507984
Abstract: Introduction: We retrospectively evaluated the efficacy of three-dimensional conformal radiotherapy (3D-CRT) for spinal schwannoma. Methods: Nine patients with spinal schwannoma were treated with 3D-CRT. All patients had a paravertebral or intraosseous component. Tumor sizes ranged from 0.8 to 8.7 cm, with a median of 3.5 cm. The prescribed dose was 50 Gy in 25 fractions at the isocenter, except for 1 patient who received 66 Gy in 33 fractions for a large sacral tumor. The follow-up period ranged from 20 to 137 months, with a median of 72 months. Results: Tumor shrinkage within 3 mm occurred in 4 patients and tumor expansion within 3 mm occurred in 3. One tumor showed neither expansion nor shrinkage at the last follow-up. One patient experienced transient expansion by 8 mm in diameter at 12 months after the completion of radiotherapy (35-43 mm), and then the tumor size remained unchanged for 7 years. No severe late toxicity a parts per thousand yen grade 3 was observed. Conclusions: Only 1 of 9 tumors showed transit expansion over 3 mm after 3D-CRT, and severe late radiation toxicity was not observed. Use of 3D-CRT should be considered a treatment option for spinal schwannoma.
Rights: © Japan Radiological Society 2015
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鬼丸 力也

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