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Three-dimensional conformal fractionated radiotherapy for spinal schwannoma with a paravertebral or an intraosseous component
| Title: | Three-dimensional conformal fractionated radiotherapy for spinal schwannoma with a paravertebral or an intraosseous component |
| Authors: | Onimaru, Rikiya Browse this author →KAKEN DB | | Hida, Kazutoshi Browse this author →KAKEN DB | | Takeda, Naoki Browse this author →KAKEN DB | | Onodera, Shunsuke Browse this author | | Nishikawa, Yukiko Browse this author | | Mori, Takashi Browse this author | | Shirato, Hiroki Browse this author →KAKEN DB |
| Keywords: | Spinal schwannoma | | Paravertebral schwannoma | | Three-dimensional conformal radiotherapy (3D-CRT) | | Fractionated radiotherapy | | Conventional fractionation |
| Issue Date: | Dec-2015 |
| Publisher: | Springer | | Japan Radiological Society |
| Journal Title: | Japanese journal of radiology |
| Volume: | 33 |
| Issue: | 12 |
| Start Page: | 757 |
| End Page: | 763 |
| Publisher DOI: | 10.1007/s11604-015-0492-4 |
| PMID: | 26507984 |
| Abstract: | Introduction: We retrospectively evaluated the efficacy of three-dimensional conformal radiotherapy (3D-CRT) for spinal schwannoma. Methods: Nine patients with spinal schwannoma were treated with 3D-CRT. All patients had a paravertebral or intraosseous component. Tumor sizes ranged from 0.8 to 8.7 cm, with a median of 3.5 cm. The prescribed dose was 50 Gy in 25 fractions at the isocenter, except for 1 patient who received 66 Gy in 33 fractions for a large sacral tumor. The follow-up period ranged from 20 to 137 months, with a median of 72 months. Results: Tumor shrinkage within 3 mm occurred in 4 patients and tumor expansion within 3 mm occurred in 3. One tumor showed neither expansion nor shrinkage at the last follow-up. One patient experienced transient expansion by 8 mm in diameter at 12 months after the completion of radiotherapy (35-43 mm), and then the tumor size remained unchanged for 7 years. No severe late toxicity a parts per thousand yen grade 3 was observed. Conclusions: Only 1 of 9 tumors showed transit expansion over 3 mm after 3D-CRT, and severe late radiation toxicity was not observed. Use of 3D-CRT should be considered a treatment option for spinal schwannoma. |
| Rights: | © Japan Radiological Society 2015 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/60829 |
| Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 鬼丸 力也
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