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Rare frequency of downbeat positioning nystagmus in spinocerebellar ataxia type 31

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Title: Rare frequency of downbeat positioning nystagmus in spinocerebellar ataxia type 31
Authors: Yabe, Ichiro Browse this author →KAKEN DB
Matsushima, Masaaki Browse this author
Yoshida, Kunihiro Browse this author →KAKEN DB
Ishikawa, Kinya Browse this author →KAKEN DB
Shirai, Shinichi Browse this author
Takahashi, Ikuko Browse this author
Sasaki, Hidenao Browse this author →KAKEN DB
Keywords: spinocerebellar ataxia type 31
spinocerebellar ataxia type 6
downbeat positioning nystagmus
spinocerebellar degeneration
cortical cerebellar atrophy
Issue Date: 15-Mar-2015
Publisher: Elsevier
Journal Title: Journal of the Neurological Sciences
Volume: 350
Issue: 1-2
Start Page: 90
End Page: 92
Publisher DOI: 10.1016/j.jns.2014.12.042
PMID: 25684342
Abstract: Spinocerebellar ataxia type 31 (SCA31) and spinocerebellar ataxia type 6 (SCA6) are the most frequent types of spinocerebellar degeneration in Japan. Previous reports described that it was difficult to distinguish SCA6 and SCA31 in clinical situations. There is not much difference except that the onset age of SCA31 is slightly higher than that of SCA6. Therefore we surveyed our medical records retrospectively, and then compared clinical symptoms of SCA6 and SCA31. As previously stated, the onset age of SCA31 is higher than that of SCA6. Gaze-evoked nystagmus is more frequent in SCA6 than in SCA31. The percentage in downbeat positioning nystagmus (DPN) is as high as 63% in SCA6. In contrast, DPN in SCA31 is rare and subtle. Our study suggests that the presence of DPN is an important sign that can differentiate SCA6 from SCA31 clinically.
Rights: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 矢部 一郎

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