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Prognostic Value of Right Ventricular Tei Index in Dogs with Myxomatous Mitral Valvular Heart Disease

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/60920

Title: Prognostic Value of Right Ventricular Tei Index in Dogs with Myxomatous Mitral Valvular Heart Disease
Authors: Nakamura, K. Browse this author →KAKEN DB
Morita, T. Browse this author
Osuga, T. Browse this author
Morishita, K. Browse this author →KAKEN DB
Sasaki, N. Browse this author →KAKEN DB
Ohta, H. Browse this author →KAKEN DB
Takiguchi, M. Browse this author →KAKEN DB
Keywords: Echocardiography
Myocardial performance index
Pulmonary hypertension
Right heart function
Issue Date: Jan-2016
Publisher: Wiley-Blackwell
Journal Title: Journal of Veterinary Internal Medicine
Volume: 30
Issue: 1
Start Page: 69
End Page: 75
Publisher DOI: 10.1111/jvim.13820
Abstract: Background: The right ventricular (RV) Tei index (TX) has a significant correlation with the severity of pulmonary hypertension. However, the role of RV dysfunction in dogs with myxomatous mitral valvular heart disease (MMVD) has not been addressed. Objectives: To investigate the correlation between right ventricular Tei-index (RVTX) and the prognosis for dogs with MMVD. Animals: Thirty client-owned dogs with MMVD. Methods: Clinical cohort study. Dogs were divided into two groups on the basis of the onset of cardiac-related death within 1 year of the first echocardiographic examination. Physical examination and echocardiographic variables were compared between the groups. Receiver operating characteristic (ROC) curves and multivariate logistic analysis were used to assess the comparative accuracy when identifying dogs with cardiac-related death. Results: The highest accuracy was obtained for RVTX with an area under the ROC curve (AUC) of 0.95 (95% confidence interval [CI] 0.81-0.99) followed by the left atrial to aortic root ratio with an AUC of 0.91 (95% CI 0.74-0.98), peak early diastolic mitral inflow velocity with an AUC of 0.84 (95% CI 0.64-0.94), and Doppler estimates of systolic pulmonary artery pressure with an AUC of 0.84 (95% CI 0.61-0.95). According to the multivariate logistic regression analysis, RVTX was the only independent correlate of cardiac-related death within 1 year. Conclusions and Clinical Importance: Right ventricular Tei-index has a strong correlation with the prognosis for dogs with MMVD. The most significant independent predictor of death was RVTX in this study.
Rights: http://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/60920
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中村 健介

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