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Serum Brain-Derived Neurotropic Factor Level Predicts Adverse Clinical Outcomes in Patients With Heart Failure

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Title: Serum Brain-Derived Neurotropic Factor Level Predicts Adverse Clinical Outcomes in Patients With Heart Failure
Authors: Fukushima, Arata Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Homma, Tsuneaki Browse this author
Masaki, Yoshihiro Browse this author
Furihata, Takaaki Browse this author
Yokota, Takashi Browse this author
Matsushima, Shouji Browse this author
Takada, Shingo Browse this author →KAKEN DB
Kadoguchi, Tomoyasu Browse this author
Oba, Koji Browse this author →KAKEN DB
Okita, Koichi Browse this author
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: Heart failure
brain-derived neurotrophic factor
exercise capacity
prognosis
Issue Date: Apr-2015
Publisher: Elsevier
Journal Title: Journal of cardiac failure
Volume: 21
Issue: 4
Start Page: 300
End Page: 306
Publisher DOI: 10.1016/j.cardfail.2015.01.003
PMID: 25639689
Abstract: Background: Brain-derived neurotropic factor (BDNF) is involved in cardiovascular diseases as well as skeletal muscle energy metabolism and depression. We investigated whether serum BDNF level was associated with prognosis in patients with heart failure (HF). Methods and Results: We measured the serum BDNF level in 58 patients with HF (59.2 ± 13.7 years old, New York Heart Association functional class I-III) at baseline, and adverse events, including all cardiac deaths and HF rehospitalizations, were recorded during the median follow-up of 20.3 months. In a univariate analysis, serum BDNF levels were significantly associated with peak oxygen capacity (β = 0.547; P = .003), anaerobic threshold (β = 0.929; P = .004), and log minute ventilation/carbon dioxide production slope (β = -10.15; P = .005), but not Patient Health Questionnaire scores (β = -0.099; P = .586). A multivariate analysis demonstrated that serum BDNF level was an independent prognostic factor of adverse events (hazard ratio 0.41, 95% confidence interval 0.20-0.84; P = .003). The receiver operating characteristic curve demonstrated that low levels of BDNF (<17.4 ng/mL) were associated with higher rates of adverse events compared with high levels of BDNF (≥17.4 ng/mL; log rank test: P < .001). Conclusions: Decreased serum BDNF levels were significantly associated with adverse outcomes in HF patients, suggesting that these levels can be a useful prognostic biomarker.
Rights: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/61457
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 絹川 真太郎

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