| Title: | Serum Brain-Derived Neurotropic Factor Level Predicts Adverse Clinical Outcomes in Patients With Heart Failure |
| Authors: | Fukushima, Arata Browse this author |
| Kinugawa, Shintaro Browse this author →KAKEN DB |
| Homma, Tsuneaki Browse this author |
| Masaki, Yoshihiro Browse this author |
| Furihata, Takaaki Browse this author |
| Yokota, Takashi Browse this author |
| Matsushima, Shouji Browse this author |
| Takada, Shingo Browse this author →KAKEN DB |
| Kadoguchi, Tomoyasu Browse this author |
| Oba, Koji Browse this author →KAKEN DB |
| Okita, Koichi Browse this author |
| Tsutsui, Hiroyuki Browse this author →KAKEN DB |
| Keywords: | Heart failure |
| brain-derived neurotrophic factor |
| exercise capacity |
| prognosis |
| Issue Date: | Apr-2015 |
| Publisher: | Elsevier |
| Journal Title: | Journal of cardiac failure |
| Volume: | 21 |
| Issue: | 4 |
| Start Page: | 300 |
| End Page: | 306 |
| Publisher DOI: | 10.1016/j.cardfail.2015.01.003 |
| PMID: | 25639689 |
| Abstract: | Background: Brain-derived neurotropic factor (BDNF) is involved in cardiovascular diseases as well as skeletal muscle energy metabolism and depression. We investigated whether serum BDNF level was associated with prognosis in patients with heart failure (HF). Methods and Results: We measured the serum BDNF level in 58 patients with HF (59.2 ± 13.7 years old, New York Heart Association functional class I-III) at baseline, and adverse events, including all cardiac deaths and HF rehospitalizations, were recorded during the median follow-up of 20.3 months. In a univariate analysis, serum BDNF levels were significantly associated with peak oxygen capacity (β = 0.547; P = .003), anaerobic threshold (β = 0.929; P = .004), and log minute ventilation/carbon dioxide production slope (β = -10.15; P = .005), but not Patient Health Questionnaire scores (β = -0.099; P = .586). A multivariate analysis demonstrated that serum BDNF level was an independent prognostic factor of adverse events (hazard ratio 0.41, 95% confidence interval 0.20-0.84; P = .003). The receiver operating characteristic curve demonstrated that low levels of BDNF (<17.4 ng/mL) were associated with higher rates of adverse events compared with high levels of BDNF (≥17.4 ng/mL; log rank test: P < .001). Conclusions: Decreased serum BDNF levels were significantly associated with adverse outcomes in HF patients, suggesting that these levels can be a useful prognostic biomarker. |
| Rights: | © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/61457 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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