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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Applications of CRSIPR/Cas9 in Cancer Research
| Title: | Applications of CRSIPR/Cas9 in Cancer Research |
| Authors: | Yue, Junming Browse this author | | Du, Ziyun Browse this author | | Zhou, Fu-Ming Browse this author | | Dong, Peixin Browse this author →KAKEN DB | | Pfeffer, Lawrence M Browse this author |
| Keywords: | Cancer | | CRISPR/Cas9 | | Application |
| Issue Date: | Mar-2016 |
| Publisher: | OMICS International |
| Journal Title: | Cancer Medicine & Anti Cancer Drugs |
| Volume: | 1 |
| Issue: | 1 |
| Start Page: | 1000103 |
| Abstract: | The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/61465 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 董 培新
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