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Applications of CRSIPR/Cas9 in Cancer Research

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Title: Applications of CRSIPR/Cas9 in Cancer Research
Authors: Yue, Junming Browse this author
Du, Ziyun Browse this author
Zhou, Fu-Ming Browse this author
Dong, Peixin Browse this author →KAKEN DB
Pfeffer, Lawrence M Browse this author
Keywords: Cancer
Issue Date: Mar-2016
Publisher: OMICS International
Journal Title: Cancer Medicine & Anti Cancer Drugs
Volume: 1
Issue: 1
Start Page: 1000103
Abstract: The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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