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Applications of CRSIPR/Cas9 in Cancer Research

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タイトル: Applications of CRSIPR/Cas9 in Cancer Research
著者: Yue, Junming 著作を一覧する
Du, Ziyun 著作を一覧する
Zhou, Fu-Ming 著作を一覧する
Dong, Peixin 著作を一覧する
Pfeffer, Lawrence M 著作を一覧する
キーワード: Cancer
発行日: 2016年 3月
出版者: OMICS International
誌名: Cancer Medicine & Anti Cancer Drugs
巻: 1
号: 1
開始ページ: 1000103
抄録: The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 董 培新


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