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Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers
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| Title: | Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers |
| Authors: | Yamada, Tamaki Browse this author →KAKEN DB | | Tsuda, Masumi Browse this author →KAKEN DB | | Wagatsuma, Takanori Browse this author | | Fujioka, Yoichiro Browse this author | | Fujioka, Mari Browse this author | | Satoh, Aya O. Browse this author | | Horiuchi, Kosui Browse this author | | Nishide, Shinya Browse this author →KAKEN DB | | Nanbo, Asuka Browse this author →KAKEN DB | | Totsuka, Yasunori Browse this author →KAKEN DB | | Haga, Hisashi Browse this author →KAKEN DB | | Tanaka, Shinya Browse this author →KAKEN DB | | Shindoh, Masanobu Browse this author →KAKEN DB | | Ohba, Yusuke Browse this author →KAKEN DB |
| Issue Date: | 24-Mar-2016 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 6 |
| Start Page: | 23545 |
| Publisher DOI: | 10.1038/srep23545 |
| Abstract: | Cellular interactions with the extracellular matrix play critical roles in tumor progression. We previously reported that receptor activator of NF-κB ligand (RANKL) specifically facilitates head and neck squamous cell carcinoma (HNSCC) progression in vivo. Here, we report a novel role for RANKL in the regulation of cell adhesion. Among the major type I collagen receptors, integrin α2 was significantly upregulated in RANKL-expressing cells, and its knockdown suppressed cell adhesion. The mRNA abundance of integrin α2 positively correlated with that of RANKL in human HNSCC tissues. We also revealed that RANK-NF-κB signaling mediated integrin α2 expression in an autocrine/paracrine manner. Interestingly, the amount of active integrin β1 on the cell surface was increased in RANKL-expressing cells through the upregulation of integrin α2 and endocytosis. Moreover, the RANK-integrin α2 pathway contributed to RANKL-dependent enhanced survival in a collagen gel and inhibited apoptosis in a xenograft model, demonstrating an important role for RANKL-mediated cell adhesion in three-dimensional environments. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/61496 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大場 雄介
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