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Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease

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Title: Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease
Authors: Tagawa, Yoshiaki Browse this author
Namba, Kenichi Browse this author →KAKEN DB
Mizuuchi, Kazuomi Browse this author
Takemoto, Yuko Browse this author
Iwata, Daiju Browse this author
Uno, Tomoe Browse this author
Fukuhara, Takako Browse this author
Hirooka, Kiriko Browse this author
Kitaichi, Nobuyoshi Browse this author →KAKEN DB
Ohno, Shigeaki Browse this author →KAKEN DB
Ishida, Susumu Browse this author →KAKEN DB
Keywords: choroidal thickening
anterior recurrence
Vogt-Koyanagi-Harada disease
enhanced depth imaging optical coherence tomography
Issue Date: Apr-2016
Publisher: BMJ Publishing Group
Journal Title: British journal of ophthalmology
Volume: 100
Issue: 4
Start Page: 473
End Page: 477
Publisher DOI: 10.1136/bjophthalmol-2014-306439
PMID: 26261230
Abstract: Aim: To assess choroidal thickness changes associated with anterior segment recurrences in patients with Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: EDI-OCT images were obtained periodically from 11 VKH disease patients (22 eyes) who were followed-up due to anterior segment recurrences. Subfoveal choroidal thickness (SCT) values at the following stages were evaluated: (1) during the remission phase, (2) one month before detecting the anterior recurrence, (3) during the anterior recurrence, and (4) after systemic prednisolone (PSL) treatment leading to remission. In comparison with SCT values in remission as baseline, the changing ratios of SCT were statistically analyzed at subsequent three stages. Results: The average of the SCT changing ratios compared to the remission phase significantly increased to 1.45 ± 0.11 during anterior segment recurrences (P=0.00044) lacking any funduscopic signs of posterior involvement. Interestingly, the average SCT ratio one month before detecting the recurrence had already increased to 1.30 ± 0.08 (P=0.002). After the PSL treatment, the ratio of SCT recovered to 0.95 ± 0.03 which was equivalent with the remission level. However, in patients with their remission SCT values less than 240 μm, the SCT ratio did not increase significantly at any time points evaluated. Conclusions: The choroid in eyes with VKH disease thickened in association with the anterior segment recurrence, and this thickening was observed prior to the recurrence. EDI-OCT may be useful for detecting latent choroidal inflammation in VKH disease, whereas it may not for patients with the relatively thin choroid.
Rights: This article has been accepted for publication in British Journal of Ophthalmology following peer review. The definitive copyedited, typeset version Tagawa Y, Namba K, Mizuuchi K, et al., Br J Ophthalmol 2016;100:473–477 is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 南場 研一

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