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Synthesis of Diazirine-Based Photoreactive Saccharin Derivatives for the Photoaffinity Labeling of Gustatory Receptors

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Title: Synthesis of Diazirine-Based Photoreactive Saccharin Derivatives for the Photoaffinity Labeling of Gustatory Receptors
Authors: Wang, Lei Browse this author
Yoshida, Takuma Browse this author
Muto, Yasuyuki Browse this author
Murai, Yuta Browse this author
Tachrim, Zetryana Puteri Browse this author
Ishida, Akiko Browse this author
Nakagawa, Shiori Browse this author
Sakihama, Yasuko Browse this author →KAKEN DB
Hashidoko, Yasuyuki Browse this author →KAKEN DB
Masuda, Katsuyoshi Browse this author →KAKEN DB
Hatanaka, Yasumaru Browse this author →KAKEN DB
Hashimoto, Makoto Browse this author →KAKEN DB
Keywords: Synthetic methods
Photoaffinity labeling
Nitrogen heterocycles
Issue Date: 18-May-2015
Publisher: Wiley-Blackwell
Journal Title: European journal of organic chemistry
Issue: 14
Start Page: 3129
End Page: 3134
Publisher DOI: 10.1002/ejoc.201500184
Abstract: Saccharin is one of the most common artificial sweeteners that has a bitter taste at high concentrations. Currently, there are no detailed functional analyses of these gustatory receptors. Therefore, we designed and synthesized photoreactive saccharin derivatives that contain a (trifluoromethyl) diazirinyl moiety at the 5- or 6-position for use as functional analysis tools for photoaffinity labeling.
Rights: The right to self-archive the accepted and peer-reviewed(but not final) version of the Contribution on the Contributor’s personal website, in the Contributor’s company/institutional repository or archive, and in certain not for profit subject-based repositories such as PubMed Central, subject to an embargo period of 12 months following publication of the final Contribution.
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋本 誠

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