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Noncanonical Wnt signaling in stromal cells regulates B-lymphogenesis through interleukin-7 expression

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Title: Noncanonical Wnt signaling in stromal cells regulates B-lymphogenesis through interleukin-7 expression
Authors: Sato, Mari Browse this author →KAKEN DB
Tamura, Masato Browse this author →KAKEN DB
Keywords: IL-7
Noncanonical Wntsignaling
Bone marrowstromalcells
Issue Date: Jul-2016
Publisher: Elsevier
Journal Title: Biochemistry and biophysics reports
Volume: 6
Start Page: 179
End Page: 184
Publisher DOI: 10.1016/j.bbrep.2016.03.017
Abstract: The regulation of early B cell development and the interaction of hematopoietic precursors with stromal cells in the bone marrow (BM) are controlled by various secreted signaling molecules. Several recent studies showed Wnt signaling involved in B-lymphogenesis through stromal cells. However, the molecules modulated by Wnt signaling in stromal cells regulating B-lymphogenesis have not been identified yet. Interleukin (IL)-7 and CXC chemokine ligand (CXCL) 12 are known to be express in stromal cells, and both molecules are essential for B-lymphogenesis. In the present study, we examined the role of Wnt signaling in regulating IL-7 and CXCL12 expression and in affecting B-lymphogenesis. In mouse stromal ST2 cells, expression of IL-7 and CXCL12 mRNA was augmented by noncanonical Wnt5a. When mouse BM-derived cells were cultured on Wnt5a-overexpressing ST2 cells, an increased number of B220+/IgM- B-lymphoid precursor cells was observed. These results show that Wnt5a regulates IL-7 gene expression in stromal cells and suggest the possibility that noncanonical Wnt regulates B-lymphogenesis via IL-7 expression in stromal cells.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田村 正人

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