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Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma
Title: | Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with concurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell carcinoma |
Authors: | Mizumachi, Takatsugu Browse this author →KAKEN DB | Homma, Akihiro Browse this author →KAKEN DB | Kakizaki, Tomohiko Browse this author | Sakashita, Tomohiro Browse this author →KAKEN DB | Kano, Satoshi Browse this author →KAKEN DB | Hatakeyama, Hiromitsu Browse this author →KAKEN DB | Tsuchiya, Kazuhiko Browse this author →KAKEN DB | Yasuda, Koichi Browse this author →KAKEN DB | Onimaru, Rikiya Browse this author →KAKEN DB | Shirato, Hiroki Browse this author →KAKEN DB | Taguchi, Jun Browse this author | Shimizu, Yasushi Browse this author →KAKEN DB | Kinoshita, Ichiro Browse this author →KAKEN DB | Akita, Hirotoshi Browse this author →KAKEN DB | Fukuda, Satoshi Browse this author →KAKEN DB |
Keywords: | Head and neck cancer | Induction chemotherapy | Chemoradiotherapy |
Issue Date: | Jun-2015 |
Publisher: | Springer |
Journal Title: | International journal of clinical oncology |
Volume: | 20 |
Issue: | 3 |
Start Page: | 431 |
End Page: | 437 |
Publisher DOI: | 10.1007/s10147-014-0726-y |
PMID: | 24993675 |
Abstract: | The aim of this study was to evaluate the feasibility of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy followed by concurrent weekly cisplatin chemoradiotherapy for patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Between 2010 and 2013, 30 patients with Stage IV HNSCC were treated in Hokkaido University Hospital with three cycles of induction chemotherapy (docetaxel 75 mg/m(2) and cisplatin 75 mg/m(2), day 1; and 5-fluorouracil 750 mg/m(2)/day 120 h continuous infusion, every 3 weeks) followed by concurrent weekly cisplatin (40 mg/m(2), on weeks 1, 2, 3, 5, 6 and 7) chemoradiotherapy. Three courses of induction chemotherapy were performed in 25 patients (83 %) with grade 3-4 toxicities during induction chemotherapy observed in 22 patients (73 %). The major toxicities were hematologic, with 22 cases (73 %) showing grade 3-4 neutropenia. Radiotherapy was completed (70 Gy) in 29 patients (97 %), while a total of 19 patients (63 %) completed five (13 patients) or six (6 patients) courses of chemotherapy. During concurrent chemoradiotherapy, no grade 4 hematological toxicities were observed. Grade 4 dermatitis was observed in one patient, and grade 3 mucositis was observed in 12 patients. There were no treatment-related deaths during the induction chemotherapy or concurrent chemoradiotherapy. The 1- and 2-year progression-free survival rates and the 1- and 2-year overall survival rates were 86 %, 72 %, and 89 %, 81 %, respectively. Sequential therapy composed of induction chemotherapy followed by concurrent weekly cisplatin chemoradiotherapy is feasible, showing encouraging results in patients with locally advanced HNSCC. Concurrent weekly cisplatin chemoradiotherapy following induction chemotherapy appears to be a suitable alternative to three-weekly high-dose cisplatin therapy. |
Rights: | The final publication is available at Springer via http://dx.doi.org/10.1007/s10147-014-0726-y |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/61985 |
Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc) 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 水町 貴諭
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