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Zinc nanoparticles induced brain lesions and behavioral changes in two Tilapia species

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Title: Zinc nanoparticles induced brain lesions and behavioral changes in two Tilapia species
Authors: Afifi, Mohamed Browse this author
Zinada, Osama A. Abu Browse this author
Ali, Haytham Browse this author
Couderchet, Michel Browse this author
Keywords: Nanoparticles
Behavioral alteration
Issue Date: Apr-2016
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 64
Issue: Supplement 2
Start Page: S161
End Page: S166
Abstract: In this study, we investigated the induced behavioral changes and neuropathology of prolonged exposure to high doses of Zn-NPs in two species of tilapia, T. nilotica and T. zilli. Fish that were treated with 2000 μg Zn-NPs /L showed severe degenerative changes and vacuolation in the neuropil, particularly of the optic tectum, with congestion of the blood vessels of both the cerebral cortex and the meninx primitive. Loss of the Purkinje cell layer of the cerebellum was noticed as well. Fish showed behavioral changes that included loss of equilibrium, slower movement and swimming sideways. No significant differences were observed between T. nilotica and T. zilli in behavioral or pathological changes. Our results highlight the Zn-NPs neurotoxicity and its accompanied neuropathology and related behavioral changes in fish. More caution is needed during the usage of Zn-NPs to avoid possible deleterious impacts on human and animal health.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 64 Supplement 2

Submitter: 獣医学部図書室

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