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Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients

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Title: Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients
Authors: Tanaka, Kimitaka Browse this author
Tsuchikawa, Takahiro Browse this author →KAKEN DB
Miyamoto, Masaki Browse this author →KAKEN DB
Maki, Takehiro Browse this author
Ichinokawa, Masaomi Browse this author
Kubota, Kanako C. Browse this author
Shichinohe, Toshiaki Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Ferrone, Soldano Browse this author
Dosaka-Akita, Hirotoshi Browse this author
Matsuno, Yoshihiro Browse this author
Kondo, Satoshi Browse this author →KAKEN DB
Keywords: histocompatibility antigens class I
antigen processing machinery
esophageal neoplasms
tissue array analysis
immunohistochemistry
Issue Date: Apr-2012
Publisher: Spandidos Publications
Journal Title: International Journal of Oncology
Volume: 40
Issue: 4
Start Page: 965
End Page: 974
Publisher DOI: 10.3892/ijo.2011.1274
PMID: 22134332
Abstract: The HLA class I antigen processing machinery (APM) plays a crucial role in the anticancer immune response. The aim of this study was to assess the clinical significance of APM components in esophageal cancer. A total of 11 esophageal cancer cell lines were evaluated by Western blot analysis for 13 HLA class I APM components. There was a different expression pattern among cancer cell lines for HLA class I heavy chain (HLA-HC), β2 microglobulin, Tapasin, TAP-1, TAP-2, LMP-7 and LMP-10. Immunohistochemical staining utilizing a tissue microarray method for HLA class I APM expression showing different expression patterns among cell lines was performed for 95 surgical specimens from patients with esophageal cancer. Prognostic factors were the down-regulation of HLA-HC, and the up-regulation of β2 microglobulin and TAP-1 in the cancer tissues. Multivariate analysis using a Cox regression model indicated that the down-regulation of HLA-HC, and up-regulation of TAP-1 in cancer tissues are independent, unfavorable prognostic factors (hazard ratio, 2.361 and 2.297; P=0.0141 and 0.0145, respectively). Although there was no significant difference in survival for selected p-stage I and II patients (n=54) in all APM components, only down-regulation of HLA-HC was an unfavorable prognostic factor by a Cox regression model for selected p-stage III and IV patients (n=41). In conclusion, the current results suggest that the down-regulation of HLA-HC in tumors is especially associated with a poor prognosis among advanced esophageal cancer patients.
Type: article
URI: http://hdl.handle.net/2115/62038
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 公貴

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