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Growth of rat parotid glands is inhibited by liquid diet feeding

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Title: Growth of rat parotid glands is inhibited by liquid diet feeding
Authors: Takahashi, Shigeru Browse this author →KAKEN DB
Uekita, Hiroki Browse this author
Kato, Tsuyoshi Browse this author
Inoue, Kiichiro Browse this author →KAKEN DB
Domon, Takanori Browse this author →KAKEN DB
Keywords: Liquid diet
Growth
Parotid gland
Acinar cell
Cell proliferation
Apoptosis
Issue Date: Jun-2015
Publisher: Churchill Livingstone
Journal Title: Tissue & cell
Volume: 47
Issue: 3
Start Page: 336
End Page: 341
Publisher DOI: 10.1016/j.tice.2015.04.003
PMID: 25956847
Abstract: This study investigated how liquid diet feeding affects the growth of parotid glands. We weaned 21-day-old rats and thereafter fed them a pellet diet (control group) or a liquid diet (experimental group) for 0, 1, 2, 4, or 8 weeks. Their parotid glands were excised, weighed, examined, and tested for 5-bromo-2'-deoxyuridine (BrdU) and cleaved caspase-3 (Casp-3) as markers of proliferation and apoptosis, respectively. Parotid gland weights were consistently smaller in experimental animals than in controls. Morphometrical analysis showed that control group acinar cells increased in area during the experiment, but experimental group acinar cells were almost unchanged. Labeling indices of BrdU in acinar cells in both groups declined during the experiment, but were consistently lower in the experimental group than in controls. Casp-3-positive acinar cells were rare in both groups, which consistently express significantly similar Casp-3 levels. Ultrastructurally, terminal portions of the experimental parotid glands consisted of a few acinar cells that were smaller than those in controls. Control acinar cells showed mitotic figures within short experimental periods, but not in experimental glands. These observations indicate that liquid diet feeding inhibits growth of parotid glands in growing rats through suppression of growth and proliferation of individual acinar cells, but not through apoptosis. (C) 2015 Elsevier Ltd. All rights reserved.
Rights: © 2015, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62058
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 茂

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