| Title: | Tumour resistance in induced pluripotent stem cells derived from naked mole-rats |
| Authors: | Miyawaki, Shingo Browse this author |
| Kawamura, Yoshimi Browse this author |
| Oiwa, Yuki Browse this author |
| Shimizu, Atsushi Browse this author |
| Hachiya, Tsuyoshi Browse this author |
| Bono, Hidemasa Browse this author →KAKEN DB |
| Koya, Ikuko Browse this author |
| Okada, Yohei Browse this author →KAKEN DB |
| Kimura, Tokuhiro Browse this author →KAKEN DB |
| Tsuchiya, Yoshihiro Browse this author |
| Suzuki, Sadafumi Browse this author →KAKEN DB |
| Onishi, Nobuyuki Browse this author →KAKEN DB |
| Kuzumaki, Naoko Browse this author →KAKEN DB |
| Matsuzaki, Yumi Browse this author |
| Narita, Minoru Browse this author →KAKEN DB |
| Ikeda, Eiji Browse this author →KAKEN DB |
| Okanoya, Kazuo Browse this author →KAKEN DB |
| Seino, Ken-ichiro Browse this author →KAKEN DB |
| Saya, Hideyuki Browse this author →KAKEN DB |
| Okano, Hideyuki Browse this author →KAKEN DB |
| Miura, Kyoko Browse this author |
| Issue Date: | 10-May-2016 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Nature communications |
| Volume: | 7 |
| Start Page: | 11471 |
| Publisher DOI: | 10.1038/ncomms11471 |
| Abstract: | The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs) and find that NMR-iPSCs do not exhibit teratoma-forming tumorigenicity due to the species-specific activation of tumour-suppressor alternative reading frame (ARF) and a disruption mutation of the oncogene ES cell-expressed Ras (ERAS). The forced expression of Arf in mouse iPSCs markedly reduces tumorigenicity. Furthermore, we identify an NMR-specific tumour-suppression phenotype-ARF suppression-induced senescence (ASIS)-that may protect iPSCs and somatic cells from ARF suppression and, as a consequence, tumorigenicity. Thus, NMR-specific ARF regulation and the disruption of ERAS regulate tumour resistance in NMR-iPSCs. Our findings obtained from studies of NMR-iPSCs provide new insight into the mechanisms of tumorigenicity in iPSCs and cancer resistance in the NMR. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/62277 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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