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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Isolated tumor cells and micrometastases in regional lymph nodes in stage I to II endometrial cancer
This item is licensed under:Creative Commons Attribution-NonCommercial 4.0 International
| Title: | Isolated tumor cells and micrometastases in regional lymph nodes in stage I to II endometrial cancer |
| Authors: | Todo, Yukiharu Browse this author | | Kato, Hidenori Browse this author | | Okamoto, Kazuhira Browse this author | | Minobe, Shinichiro Browse this author | | Yamashiro, Katsushige Browse this author | | Sakuragi, Noriaki Browse this author →KAKEN DB |
| Keywords: | Endometrial Neoplasms | | Neoplasm Micrometastasis | | Neoplasm Recurrence, Local | | Neoplasm Staging | | Retrospective Studies |
| Issue Date: | Jan-2016 |
| Publisher: | Korean Society of Gynecologic Oncology and Colposcopy |
| Journal Title: | Journal of gynecologic oncology |
| Volume: | 27 |
| Issue: | 1 |
| Start Page: | e1 |
| Publisher DOI: | 10.3802/jgo.2016.27.e1 |
| Abstract: | Objective: The aim of this study was to clarify the clinical significance of isolated tumor cells (ITCs) or micrometastasis (MM) in regional lymph nodes in patients with International Federation of Gynecology and Obstetrics (FIGO) stage Ito II endometrial cancer. Methods: In this study, a series of 63 patients with FIGO stage Ito II were included, who had at least one of the following risk factors for recurrence: G3 endometrioid/serous/clear cell adenocarcinomas, deep myometrial invasion, cervical involvement, lympho-vascular space invasion, and positive peritoneal cytology. These cases were classified as intermediate-risk endometrial cancer. Ultrastaging by multiple slicing, staining with hematoxylin and eosin and cytokeratin, and microscopic examination was performed on regional lymph nodes that had been diagnosed as negative for metastases. Results: Among 61 patients in whom paraffin-embedded block was available, ITC/MM was identified in nine patients (14.8%). Deep myometrial invasion was significantly associated with ITC/MM (p=0.028). ITC/MM was an independent risk factor for extrapelvic recurrence (hazard ratio, 17.9; 95% confidence interval [CI], 1.4 to 232.2). The 8-year overall survival (OS) and recurrence-free survival (RFS) rates were more than 20% lower in the ITC/MM group than in the node-negative group (OS, 71.4% vs. 91.9%; RFS, 55.6% vs. 84.0%), which were statistically not significant (OS, p=0.074; RFS, p=0.066). Time to recurrence tended to be longer in the ITC/MM group than in the node-negative group (median, 49 months vs. 16.5 months; p=0.080). Conclusions: It remains unclear whether ITC/MM have an adverse influence on prognosis of intermediate-risk endometrial cancer. A multicenter cooperative study is needed to clarify the clinical significance of ITC/MM. |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/62281 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 櫻木 範明
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