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Evaluation of the relative biological effectiveness of spot-scanning proton irradiationin vitro

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Title: Evaluation of the relative biological effectiveness of spot-scanning proton irradiationin vitro
Authors: Maeda, Kenichiro Browse this author
Yasui, Hironobu Browse this author →KAKEN DB
Matsuura, Taeko Browse this author →KAKEN DB
Yamamori, Tohru Browse this author →KAKEN DB
Suzuki, Motofumi Browse this author
Nagane, Masaki Browse this author
Nam, Jin-Min Browse this author
Inanami, Osamu Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: relative biological effectiveness
spot scanning
proton therapy
Issue Date: Jun-2016
Publisher: Oxford University Press
Journal Title: Journal of Radiation Research
Volume: 57
Issue: 3
Start Page: 307
End Page: 311
Publisher DOI: 10.1093/jrr/rrv101
Abstract: Variations in relative biological effectiveness (RBE) from a fixed value of 1.1 are critical in proton beam therapy. To date, studies estimating RBE at multiple positions relative to the spread-out Bragg peak (SOBP) have been predominantly performed using passive scattering methods, and limited data are available for spot-scanning beams. Thus, to investigate the RBE of spot-scanning beams, Chinese hamster fibroblast V79 cells were irradiated using the beam line at the Hokkaido University Hospital Proton Therapy Center. Cells were placed at six different depths, including the entrance of the proton beam and the proximal and distal part of the SOBP. Surviving cell fractions were analyzed using colony formation assay, and cell survival curves were obtained by the curve fitted using a linear-quadratic model. RBE10 and RBE37 were 1.15 and 1.21 at the center of the SOBP, respectively. In contrast, the distal region showed higher RBE values (1.50 for RBE10 and 1.85 for RBE37). These results are in line with those of previous studies conducted using passive scattering proton beams. Taken together, these data strongly suggest that variations in RBE should be considered during treatment planning for spot-scanning beams as well as for passive scattering proton beams.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 前田 憲一郎

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