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Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma

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Title: Immunohistochemical detection of a potential molecular therapeutic target for canine hemangiosarcoma
Authors: Adachi, Mami Browse this author
Hoshino, Yuki Browse this author →KAKEN DB
Izumi, Yusuke Browse this author
Takagi, Satoshi Browse this author →KAKEN DB
Keywords: canine hemangiosarcoma dog
MAPK pathway
PI3K/Akt/m-TOR pathway
receptor tyrosine kinase
Issue Date: Apr-2016
Publisher: 公益社団法人 日本獣医学会
Journal Title: Journal of Veterinary Medical Science
Volume: 78
Issue: 4
Start Page: 649
End Page: 656
Publisher DOI: 10.1292/jvms.15-0625
Abstract: Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm of dogs for which there is currently no effective treatment. A recent study suggested that receptor tyrosine kinases (RTKs), the PI3K/Akt/m-TOR and MAPK pathways are all activated in canine and human HSA. The aim of the present study was to investigate the overexpression of these proteins by immunohistochemistry in canine splenic HSA to identify potential molecular therapeutic targets. A total of 10 splenic HSAs and two normal splenic samples surgically resected from dogs were sectioned and stained with hematoxylin and eosin for histological diagnosis or analyzed using immunohistochemistry. The expression of RTKs, c-kit, VEGFR-2 and PDGFR-2, as well as PI3K/Akt/m-TOR and MEK was higher in canine splenic HSAs compared to normal spleens. These proteins may therefore be potential therapeutic targets in canine splenic HSA.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高木 哲

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