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First total synthesis of (+)-epogymnolactam, a novel autophagy inducer

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Title: First total synthesis of (+)-epogymnolactam, a novel autophagy inducer
Authors: Okado, Yuji Browse this author
Shigetomi, Kengo Browse this author
Mitsuhashi, Shinya Browse this author →KAKEN DB
Ubukata, Makoto Browse this author →KAKEN DB
Issue Date: Dec-2015
Publisher: 日本抗生物質学術協議会
Journal Title: Journal of antibiotics
Volume: 68
Issue: 12
Start Page: 721
End Page: 724
Publisher DOI: 10.1038/ja.2015.63
PMID: 26014720
Abstract: A novel autophagy inducer, (+)-epogymnolactam (1), was first synthesized from cis-4-benzyloxy-2-butene-1-ol (2) in eight steps. A reliable preparation of optically pure epoxy alcohol (+)-3 from monobenzyl derivative (2) was established by a tandem strategy, Sharpless epoxidation/lipase kinetic resolution.
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 生方 信

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