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Isolation and characterization of tick-borne encephalitis virus from Ixodes persulcatus in Mongolia in 2012

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Title: Isolation and characterization of tick-borne encephalitis virus from Ixodes persulcatus in Mongolia in 2012
Authors: Muto, Memi Browse this author
Bazartseren, Boldbaatar Browse this author
Tsevel, Bazartseren Browse this author
Dashzevge, Erdenechimeg Browse this author
Yoshii, Kentaro Browse this author →KAKEN DB
Kariwa, Hiroaki Browse this author →KAKEN DB
Keywords: Flavivirus
Tick-borne encephalitis
Mongolia
Issue Date: Jul-2015
Publisher: Elsevier
Journal Title: Ticks and Tick-Borne Diseases
Volume: 6
Issue: 5
Start Page: 623
End Page: 629
Publisher DOI: 10.1016/j.ttbdis.2015.05.006
PMID: 26025267
Abstract: Tick-borne encephalitis virus (TBEV) is a zoonotic virus belonging to the genus Flavivirus, in the family Flaviviridae. The virus, which is endemic in Europe and northern parts of Asia, causes severe encephalitis. Tick-borne encephalitis (TBE) has been reported in Mongolia since the 1980s, but details about the biological characteristics of the endemic virus are lacking. In this study, 680 ticks (Ixodes persulcatus) were collected in Selenge aimag, northern Mongolia, in 2012. Nine Mongolian TBEV strains were isolated from tick homogenates. A sequence analysis of the envelope protein gene revealed that all isolates belonged to the Siberian subtype of TBEV. Two strains showed similar growth properties in cultured cells, but their virulence in mice differed. Whole genome sequencing revealed only thirteen amino acid differences between these Mongolian TBEV strains. Our results suggest that these naturally occurring amino acid mutations affected the pathogenicity of Mongolian TBEV. Our results may be an important platform for monitoring TBEV to evaluate the epidemiological risk in TBE endemic areas of Mongolia. (C) 2015 Elsevier GmbH. All rights reserved.
Rights: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62341
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 好井 健太朗

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