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Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/62349

Title: Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis
Authors: Oouchi, Manabu Browse this author
Hasebe, Akira Browse this author →KAKEN DB
Hata, Hironobu Browse this author →KAKEN DB
Segawa, Taku Browse this author
Yamazaki, Yutaka Browse this author →KAKEN DB
Yoshida, Yasuhiro Browse this author
Kitagawa, Yoshimasa Browse this author →KAKEN DB
Shibata, Ken-ichiro Browse this author →KAKEN DB
Keywords: toll-like receptors
natural killer cell activity
oral candidiasis
Issue Date: Jul-2015
Publisher: Wiley-Blackwell
Journal Title: Oral diseases
Volume: 21
Issue: 5
Start Page: 645
End Page: 651
Publisher DOI: 10.1111/odi.12329
PMID: 25704085
Abstract: ObjectiveRoles of aging or immune responses mediated by Toll-like receptors and natural killer cell in the onset or progression of human candidiasis remain unclear. This study was designed to elucidate the roles using peripheral blood mononuclear cells from healthy donors and patients with oral candidiasis. Subjects and methodsSubjects tested were healthy volunteers and patients who visited Dental Clinical Division of Hokkaido University Hospital. The patients with oral candidiasis included 39 individuals (25-89years of age) with major complaints on pain in oral mucosa and/or dysgeusia. Healthy volunteers include students (25-35years of age) and teaching staffs (50-65years of age) of Hokkaido University Graduate School of Dental Medicine. ResultsFunctions of Toll-like receptors 2 and 4 were downregulated significantly and the natural killer activity was slightly, but not significantly downregulated in aged healthy volunteers compared with healthy young volunteers. Functions of Toll-like receptors 2 and 4 and the natural killer activity were significantly downregulated in patients with oral candidiasis compared with healthy volunteers. ConclusionDownregulation of functions of Toll-like receptors 2 and 4 as well as natural killer activity is suggested to be associated with the onset or progression of oral candidiasis in human.
Rights: This is the peer reviewed version of the following article: [Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis], which has been published in final form at [10.1111/odi.12329]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/62349
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 柴田 健一郎

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