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Administration of unfractionated heparin with prolonged fasting could reduce physiological 18F-fluorodeoxyglucose uptake in the heart

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/62353

Title: Administration of unfractionated heparin with prolonged fasting could reduce physiological 18F-fluorodeoxyglucose uptake in the heart
Authors: Masuda, Atsuro Browse this author
Naya, Masanao Browse this author →KAKEN DB
Manabe, Osamu Browse this author →KAKEN DB
Magota, Keiichi Browse this author →KAKEN DB
Yoshinaga, Keiichiro Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: Cardiac
PET
inflammation
physiological FDG uptake
Issue Date: Jun-2016
Publisher: SAGE Publications
Journal Title: Acta radiologica
Volume: 57
Issue: 6
Start Page: 661
End Page: 668
Publisher DOI: 10.1177/0284185115600916
PMID: 26339041
Abstract: Background: The physiological uptake of 18F-fluorodeoxyglucose (FDG) in the heart often interferes with the accurate diagnosis of inflammatory cardiac diseases (CDs). Unfractionated heparin (UFH) administration may suppress its uptake through the alteration of myocardial metabolism. Purpose: To clarify the effectiveness of UFH administration to suppress the physiological FDG uptake in the heart. Material and Methods: The physiological FDG uptake in the heart was compared among 178 patients who fasted less than 18 h, 37 patients who fasted more than 18 h, and 64 patients who fasted more than 18 h and were administered UFH (UFH-CD group) prior to FDG PET/CT. Free fatty acid (FFA), triglyceride, insulin, and blood glucose levels were measured after UFH administration. Myocardial FDG uptake was evaluated by visual assessment and on the basis of maximum standardized uptake value (SUVmax). Results: In the UFH-CD group, the FFA level increased 15 min after UFH administration (P < 0.01). Blood glucose and insulin levels remained unchanged (P = NS). FDG physiological uptake was observed in 69% of the patients who fasted less than 18 h, 38% of the patients fasted more than 18 h, and 22% of the UFH-CD group (P < 0.01 for trend). SUVmax decreased in the UFH-CD group compared with the patients who fasted less than 18 h (P < 0.01) and the patients who fasted more than 18 h (P = 0.029). Conclusion: UFH administration and fasting more than 18 h could effectively suppress FDG physiological uptake in the heart and can be a useful method of detecting inflammatory CDs and tumors.
Type: article (author version)
URI: http://hdl.handle.net/2115/62353
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 納谷 昌直

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