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Herbal medicines for the treatment of cancer chemotherapy-induced side effects

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Title: Herbal medicines for the treatment of cancer chemotherapy-induced side effects
Authors: Ohnishi, Shunsuke Browse this author →KAKEN DB
Takeda, Hiroshi Browse this author →KAKEN DB
Keywords: Kampo
rikkunshito
hangeshashinto
goshajinkigan
chemotherapy-induced side effects
Issue Date: 10-Feb-2015
Publisher: Frontiers Media
Journal Title: Frontiers in Pharmacology
Volume: 6
Start Page: 14
Publisher DOI: 10.3389/fphar.2015.00014
Abstract: Accumulating evidence suggests that Japanese herbal medicines, called Kampo, have beneficial effects on cancer chemotherapy-induced side effects. Rikkunshito ameliorates cisplatin-induced anorexia through an antagonistic effect on the 5-HT receptors and by increasing the serum ghrelin levels. Hangeshashinto improves irinotecan-induced diarrhea and chemotherapy-induced mucositis by inhibiting the activity of β-glucuronidase as well as the synthesis of prostaglandin E2. Goshajinkigan prevents oxaliplatin-induced neurotoxicity, possibly through suppressing functional alterations of the transient receptor potential channels. In this review, we will summarize the currently available literature regarding the clinical efficacy and potential mechanisms of Kampo medicines in the treatment of cancer chemotherapy-induced side effects.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/62387
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大西 俊介

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