| Title: | Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan |
| Authors: | Maishi, Nako Browse this author →KAKEN DB |
| Ohba, Yusuke Browse this author →KAKEN DB |
| Akiyama, Kosuke Browse this author →KAKEN DB |
| Ohga, Noritaka Browse this author →KAKEN DB |
| Hamada, Jun-ichi Browse this author →KAKEN DB |
| Nagao-Kitamoto, Hiroko Browse this author |
| Alam, Mohammad Towfik Browse this author |
| Yamamoto, Kazuyuki Browse this author |
| Kawamoto, Taisuke Browse this author |
| Inoue, Nobuo Browse this author →KAKEN DB |
| Taketomi, Akinobu Browse this author →KAKEN DB |
| Shindoh, Masanobu Browse this author →KAKEN DB |
| Hida, Yasuhiro Browse this author →KAKEN DB |
| Hida, Kyoko Browse this author →KAKEN DB |
| Issue Date: | 13-Jun-2016 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 6 |
| Start Page: | 28039 |
| Publisher DOI: | 10.1038/srep28039 |
| Abstract: | Tumour blood vessels are gateways for distant metastasis. Recent studies have revealed that tumour endothelial cells (TECs) demonstrate distinct phenotypes from their normal counterparts. We have demonstrated that features of TECs are different depending on tumour malignancy, suggesting that TECs communicate with surrounding tumour cells. However, the contribution of TECs to metastasis has not been elucidated. Here, we show that TECs actively promote tumour metastasis through a bidirectional interaction between tumour cells and TECs. Co-implantation of TECs isolated from highly metastatic tumours accelerated lung metastases of low metastatic tumours. Biglycan, a small leucine-rich repeat proteoglycan secreted from TECs, activated tumour cell migration via nuclear factor-kappa B and extracellular signal-regulated kinase 1/2. Biglycan expression was upregulated by DNA demethylation in TECs. Collectively, our results demonstrate that TECs are altered in their microenvironment and, in turn, instigate tumour cells to metastasize, which is a novel mechanism for tumour metastasis. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/62446 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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