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Application of collagen hydrogel/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs
| Title: | Application of collagen hydrogel/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs |
| Authors: | Kosen, Yuta Browse this author | | Miyaji, Hirofumi Browse this author →KAKEN DB | | Kato, Akihito Browse this author →KAKEN DB | | Sugaya, Tsutomu Browse this author →KAKEN DB | | Kawanami, Masamitsu Browse this author →KAKEN DB |
| Keywords: | Collagen hydrogel/sponge scaffold | | Periodontal wound healing | | Class II furcation defects | | Dog |
| Issue Date: | Oct-2012 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Journal of Periodontal Research |
| Volume: | 47 |
| Issue: | 5 |
| Start Page: | 626 |
| End Page: | 634 |
| Publisher DOI: | 10.1111/j.1600-0765.2012.01475.x |
| PMID: | 22443229 |
| Abstract: | Background and Objective: A three-dimensional scaffold may play an important role in periodontal tissue engineering. We prepared bio-safe collagen hydrogel, which exhibits properties similar to those of native extracellular matrix. The aim of this study was to examine the effect of implantation of collagen hydrogel/sponge scaffold on periodontal wound healing in class II furcation defects in dogs.
Material and Methods: The collagen hydrogel/sponge scaffold was prepared by injecting collagen hydrogel, cross-linked to the ascorbate-copper ion system, into a collagen sponge. Class II furcation defects (of 5 mm depth and 3 mm width) were surgically created in beagle dogs. The exposed root surface was planed and demineralized with EDTA. In the experimental group, the defect was filled with collagen hydrogel/sponge scaffold. In the control group, no implantation was performed. Histometric parameters were evaluated 2 and 4 wk after surgery.
Results: At 2 wk, the collagen hydrogel/sponge scaffold displayed high biocompatibility and biodegradability with numerous cells infiltrating the scaffold. In the experimental group, reconstruction of alveolar bone and cementum was frequently observed 4 wk after surgery. Periodontal ligament tissue was also re-established between alveolar bone and cementum. Volumes of new bone, new cementum and new periodontal ligament were significantly greater in the experimental group than in the control group. In addition, epithelial down-growth was suppressed by application of collagen hydrogel.
Conclusion: The collagen hydrogel/sponge scaffold possessed high tissue compatibility and degradability. Implantation of the scaffold facilitated periodontal wound healing in class II furcation defects in beagle dogs. |
| Rights: | This is the peer reviewed version of the following article: [Application of collagen hydrogel/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs], which has been published in final form at [http://dx.doi.org/10.1111/j.1600-0765.2012.01475.x]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62510 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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