| Title: | Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer with PTV < 100 cc using a continual reassessment method (JCOG0702) |
| Authors: | Onimaru, Rikiya Browse this author →KAKEN DB |
| Shirato, Hiroki Browse this author →KAKEN DB |
| Shibata, Taro Browse this author |
| Hiraoka, Masahiro Browse this author →KAKEN DB |
| Ishikura, Satoshi Browse this author |
| Karasawa, Katsuyuki Browse this author |
| Matsuo, Yukinori Browse this author →KAKEN DB |
| Kokubo, Masaki Browse this author →KAKEN DB |
| Shioyama, Yoshiyuki Browse this author →KAKEN DB |
| Matsushita, Haruo Browse this author →KAKEN DB |
| Ito, Yoshinori Browse this author |
| Onishi, Hiroshi Browse this author →KAKEN DB |
| Keywords: | Phase I study |
| Continual reassessment method |
| Non-small cell lung cancer (NSCLC) |
| Stereotactic body radiotherapy |
| SBRT |
| Issue Date: | Aug-2015 |
| Publisher: | Elsevier |
| Journal Title: | Radiotherapy and oncology |
| Volume: | 116 |
| Issue: | 2 |
| Start Page: | 276 |
| End Page: | 280 |
| Publisher DOI: | 10.1016/j.radonc.2015.07.008 |
| PMID: | 26233591 |
| Abstract: | Purpose: To estimate the maximum tolerated dose (MTD) and to determine the recommended dose (RD) of stereotactic body radiation therapy (SBRT) for peripheral T2N0M0 non-small cell carcinoma (NSCLC) with target volume (PTV) < 100 cc. Materials and methods: The continual reassessment method (CRM) was used to determine the dose level that patients should be assigned to and to estimate the MTD. Dose limiting toxicity (DLT) was grade 3 radiation pneumonitis (RP) within 180 days after the start of SBRT, grade 2 RP was used as a surrogate DLT. The RD was equal to the MTD. The dose was prescribed at D95 of the PTV. Results: Fifteen patients were accrued. Only 1 experienced grade 2 RP at 60 Gy in 4 fractions. It was difficult to fulfill the dose constraints at 60 Gy in 4 fractions, and the maximum dose level assigned by CRM was changed to 55 Gy in 4 fractions. The lower limit of 95% of the credible interval exceeded the adjacent level, and the RD was determined as 55 Gy in 4 fractions. Conclusions: The RD of SBRT for peripheral T2N0M0 NSCLC with PTV < 100 cc was determined to be 55 Gy in 4 fractions. |
| Rights: | © 2015, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62578 |
| Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
