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Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions
| Title: | Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions |
| Authors: | Suda, Goki Browse this author →KAKEN DB | | Yamamoto, Yoshiya Browse this author | | Nagasaka, Astushi Browse this author | | Furuya, Ken Browse this author | | Kudo, Mineo Browse this author | | Chuganji, Yoshimichi Browse this author | | Tsukuda, Yoko Browse this author | | Tsunematsu, Seiji Browse this author | | Sato, Fumiyuki Browse this author | | Terasita, Katsumi Browse this author | | Nakai, Masato Browse this author | | Horimoto, Hiromasa Browse this author | | Sho, Takuya Browse this author | | Natsuizaka, Mitsuteru Browse this author | | Ogawa, Kouji Browse this author | | Ohnishi, Shunsuke Browse this author →KAKEN DB | | Chuma, Makoto Browse this author →KAKEN DB | | Fujita, Yasuyuki Browse this author | | Abe, Riichiro Browse this author →KAKEN DB | | Taniguchi, Miki Browse this author | | Nakagawa, Mina Browse this author →KAKEN DB | | Asahina, Yasuhiro Browse this author →KAKEN DB | | Sakamoto, Naoya Browse this author →KAKEN DB |
| Keywords: | drug-induced hypersensitivity syndrome | | granulysin | | hepatitis C virus | | telaprevir | | toxic epidermal necrolysis | | HCV | | TEN | | DIHS |
| Issue Date: | Aug-2015 |
| Publisher: | Wiley |
| Journal Title: | Hepatology research |
| Volume: | 45 |
| Issue: | 8 |
| Start Page: | 837 |
| End Page: | 845 |
| Publisher DOI: | 10.1111/hepr.12421 |
| PMID: | 25211174 |
| Abstract: | Aim: Telaprevir-based therapy for chronic hepatitis C patients is effective; however, the high prevalence of dermatological reactions is an outstanding issue. The mechanism and characteristics of such adverse reactions are unclear; moreover, predictive factors remain unknown. Granulysin was recently reported to be upregulated in the blisters of patients with Stevens-Johnson syndrome (SJS). Therefore, we investigated the risk factors for severe telaprevir-induced dermatological reactions as well as the association between serum granulysin levels and the severity of such reactions. Methods: A total of 89 patients who received telaprevir-based therapy and had complete clinical information were analyzed. We analyzed the associations between dermatological reactions and clinical factors. Next, we investigated the time-dependent changes in serum granulysin levels in five and 14 patients with grade 3 and non-grade 3 dermatological reactions, respectively. Results: Of the 89 patients, 57 patients had dermatological reactions, including nine patients with grade 3. Univariate analysis revealed that grade 3 dermatological reactions were significantly associated with male sex. Moreover, serum granulysin levels were significantly associated with the severity of dermatological reactions. Three patients with grade 3 dermatological reaction had severe systemic manifestations including SJS, drug-induced hypersensitivity syndrome, and systemic lymphoid swelling and high-grade fever; all were hospitalized. Importantly, among the three patients, two patients' serum granulysin levels exceeded 8ng/mL at onset and symptoms deteriorated within 6 days. Conclusion: Male patients are at high risk for severe telaprevir-induced dermatological reactions. Moreover, serum granulysin levels are significantly associated with the severity of dermatological reactions and may be a predictive factor in patients treated with telaprevir-based therapy. |
| Rights: | This is the peer reviewed version of the following article: Suda, G., Yamamoto, Y., Nagasaka, A., Furuya, K., Kudo, M., Chuganji, Y., Tsukuda, Y., Tsunematsu, S., Sato, F., Terasita, K., Nakai, M., Horimoto, H., Sho, T., Natsuizaka, M., Ogawa, K., Ohnishi, S., Chuma, M., Fujita, Y., Abe, R., Taniguchi, M., Nakagawa, M., Asahina, Y., Sakamoto, N., (2015) Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions. Hepatol Res, 45: 837–845., which has been published in final form at http://doi.org/10.1111/hepr.12421. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62582 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 須田 剛生
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