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Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families

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Title: Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families
Authors: Bamai, Yu Ait Browse this author
Araki, Atsuko Browse this author →KAKEN DB
Kawai, Toshio Browse this author
Tsuboi, Tazuru Browse this author
Yoshioka, Eiji Browse this author →KAKEN DB
Kanazawa, Ayako Browse this author →KAKEN DB
Cong, Shi Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Children
Phthalate metabolites
Mother-child pairs
Father-child pairs
Phthalate exposure
Issue Date: Jul-2015
Publisher: Elsevier
Journal Title: International journal of hygiene and environmental health
Volume: 218
Issue: 5
Start Page: 461
End Page: 470
Publisher DOI: 10.1016/j.ijheh.2015.03.013
PMID: 25888094
Abstract: We measured urinary phthalate metabolites, including di-n-butyl phthalate (DnBP), di-isobutyl phthalate, benzyl butyl phthalate (BBzP), and di(2-ethylhexyl) phthalate (DEHP), from 178 school-aged children and their 284 family members using gas chromatography-mass spectrometry, and we calculated daily phthalate intakes. The highest median levels of phthalate metabolites were for mono-isobutyl phthalate in all participants except schoolchildren, where the highest levels were for mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP). Comparing the schoolchildren with their parents, the schoolchildren had significantly higher urinary metabolites for MEOHP, mono-(2-ethyl-5-carboxypentyl) phthalate, and EDEHP. Regarding daily intakes, the schoolchildren had significantly higher daily intakes of DnBP, BBzP, and EDEHP. All phthalate metabolite and sums of metabolite levels in the schoolchildren were positively correlated with their mothers' levels, except for MEHP, whereas fathers were less correlated with their children. The DEHP intake in this study was higher than that of most other studies. Moreover, 10% of the children and 3% of the adults exceeded the Reference Dose (RfD) value (20 mu g/kg/day) of the U.S. Environmental Protection Agency, which indicates that it is important to focus on children's DEHP exposure because the children exceeded the RID more than adults among the same families who shared similar exposure sources. Our results will contribute to considerations of the regulations for some phthalates and the actual phthalate exposure levels in the Japanese population. (C) 2015 Elsevier GmbH. All rights reserved.
Rights: ©2015, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62589
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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