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Testicular oocytes in MRL/MpJ mice possess similar morphological, genetic, and functional characteristics to ovarian oocytes
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| Title: | Testicular oocytes in MRL/MpJ mice possess similar morphological, genetic, and functional characteristics to ovarian oocytes |
| Authors: | Otsuka-Kanazawa, Saori Browse this author →KAKEN DB | | Ichii, Osamu Browse this author →KAKEN DB | | Kon, Yasuhiro Browse this author →KAKEN DB |
| Keywords: | DNA methylation | | H3K9me2 | | Meiosis | | MRL/MpJ mouse | | Oogenesis | | Testicular oocytes |
| Issue Date: | Aug-2015 |
| Publisher: | Elsevier |
| Journal Title: | Mechanisms of development |
| Volume: | 137 |
| Start Page: | 23 |
| End Page: | 32 |
| Publisher DOI: | 10.1016/j.mod.2015.04.002 |
| PMID: | 25892298 |
| Abstract: | In general, mammalian males produce only spermatozoa in their testes and females produce only oocytes in their ovaries. However, newborn MRL/MpJ male mice produce oocytes within their testes. In this study, we examined the initiation and progression of oogenesis in fetal and neonatal MRL/MpJ mouse testes and evaluated the characteristics of testicular oocytes. Germ cells with positive reactions to oogenesis markers such as NOBOX oogenesis homeobox and synaptonemal complex protein 3 were observed in the MRL/MpJ fetal testes on embryonic day 18.5. These fetal testicular oocytes possessed maternal-specific methylation patterns of histone and DNA. The level of DNA methylation was still low in postnatal testicular oocytes at day 14 after birth. Additionally, the postnatal testicular oocytes contained both X and Y chromosomes and had the ability to fuse with sperm. These results suggest that some XY germ cells in fetal testes of MRL/MpJ mice enter meiosis prematurely, undergo oogenesis, and differentiate into oocytes. In addition, MRL/MpJ testicular oocytes have the ability to carry on oogenesis before and shortly after birth until they obtain some of the morphological, epigenetic, and functional characteristics of oocytes. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
| Rights: | ©2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62590 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大塚 沙織
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