| Title: | Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy |
| Authors: | Kasahara, Kohei Browse this author |
| Onozawa, Masahiro Browse this author →KAKEN DB |
| Miyashita, Naohiro Browse this author |
| Yokohata, Emi Browse this author |
| Yoshida, Miho Browse this author |
| Kanaya, Minoru Browse this author |
| Kosugi-Kanaya, Mizuha Browse this author |
| Takemura, Ryo Browse this author |
| Takahashi, Shojiro Browse this author |
| Sugita, Junichi Browse this author |
| Shigematsu, Akio Browse this author |
| Takahata, Mutsumi Browse this author |
| Fujisawa, Shinichi Browse this author |
| Hashimoto, Daigo Browse this author |
| Fujimoto, Katsuya Browse this author |
| Endo, Tomoyuki Browse this author |
| Kondo, Takeshi Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Issue Date: | 2016 |
| Publisher: | Hindawi |
| Journal Title: | Case reports in hematology |
| Volume: | 2016 |
| Start Page: | 2373902 |
| Publisher DOI: | 10.1155/2016/2373902 |
| Abstract: | We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after induction therapy showed 45,XY,-7,inv(9)(p12q13)c[19]/46,XY,inv(9)(p12q13)c[1]. Retrospective FISH analysis revealed a cryptic monosomy 7 clone in the initial AML sample. The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage. Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7. We concluded that one clone was de novo AMoL with chromosome 6, 8, 11, 13, and 19 trisomy and that the other was acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) with chromosome 7 monosomy showing different responses to chemotherapy. Simultaneous onset of cytogenetically unrelated hematological malignancies that each have a different disease status is a rare phenomenon but is important to diagnose for a correct understanding of the disease status and for establishing an appropriate treatment strategy. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/62617 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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