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Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy

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Title: Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
Authors: Kasahara, Kohei Browse this author
Onozawa, Masahiro Browse this author →KAKEN DB
Miyashita, Naohiro Browse this author
Yokohata, Emi Browse this author
Yoshida, Miho Browse this author
Kanaya, Minoru Browse this author
Kosugi-Kanaya, Mizuha Browse this author
Takemura, Ryo Browse this author
Takahashi, Shojiro Browse this author
Sugita, Junichi Browse this author
Shigematsu, Akio Browse this author
Takahata, Mutsumi Browse this author
Fujisawa, Shinichi Browse this author
Hashimoto, Daigo Browse this author
Fujimoto, Katsuya Browse this author
Endo, Tomoyuki Browse this author
Kondo, Takeshi Browse this author →KAKEN DB
Teshima, Takanori Browse this author →KAKEN DB
Issue Date: 2016
Publisher: Hindawi
Journal Title: Case reports in hematology
Volume: 2016
Start Page: 2373902
Publisher DOI: 10.1155/2016/2373902
Abstract: We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after induction therapy showed 45,XY,-7,inv(9)(p12q13)c[19]/46,XY,inv(9)(p12q13)c[1]. Retrospective FISH analysis revealed a cryptic monosomy 7 clone in the initial AML sample. The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage. Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7. We concluded that one clone was de novo AMoL with chromosome 6, 8, 11, 13, and 19 trisomy and that the other was acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) with chromosome 7 monosomy showing different responses to chemotherapy. Simultaneous onset of cytogenetically unrelated hematological malignancies that each have a different disease status is a rare phenomenon but is important to diagnose for a correct understanding of the disease status and for establishing an appropriate treatment strategy.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 笠原 耕平

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