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The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

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Title: The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
Other Titles: RIG-I functions as a dual effector against HBV
Authors: Sato, Seiichi Browse this author
Li, Kai Browse this author
Kameyama, Takeshi Browse this author →KAKEN DB
Hayashi, Takaya Browse this author
Ishida, Yuji Browse this author
Murakami, Shuko Browse this author →KAKEN DB
Watanabe, Tsunamasa Browse this author →KAKEN DB
Iijima, Sayuki Browse this author →KAKEN DB
Sakurai, Yu Browse this author
Watashi, Koichi Browse this author →KAKEN DB
Tsutsumi, Susumu Browse this author
Sato, Yusuke Browse this author →KAKEN DB
Akita, Hidetaka Browse this author →KAKEN DB
Wakita, Takaji Browse this author →KAKEN DB
Rice, Charles M. Browse this author
Harashima, Hideyoshi Browse this author →KAKEN DB
Kohara, Michinori Browse this author →KAKEN DB
Tanaka, Yasuhito Browse this author →KAKEN DB
Takaoka, Akinori Browse this author →KAKEN DB
Issue Date: 20-Jan-2015
Publisher: Cell Press
Journal Title: Immunity
Volume: 42
Issue: 1
Start Page: 123
End Page: 132
Publisher DOI: 10.1016/j.immuni.2014.12.016
PMID: 25557055
Abstract: Host innate recognition triggers key immune responses for viral elimination. The sensing mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream signaling events remain to be fully clarified. Here we found that type III but not type I interferons are predominantly induced in human primary hepatocytes in response to HBV infection, through retinoic acid-inducible gene-I (RIG-I)-mediated sensing of the 5'-ε region of HBV pregenomic RNA. In addition, RIG-I could also counteract the interaction of HBV polymerase (P protein) with the 5'-ε region in an RNA-binding dependent manner, which consistently suppressed viral replication. Liposome-mediated delivery and vector-based expression of this ε region-derived RNA in liver abolished the HBV replication in human hepatocyte-chimeric mice. These findings identify an innate recognition mechanism by which RIG-I dually functions as an HBV sensor activating innate signaling and to counteract viral polymerase in human hepatocytes.
Description: Supplemental materials are available on the publisher's website.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高岡 晃教

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