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Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome


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タイトル: Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome
著者: Shinmei, Yasuhiro 著作を一覧する
Nitta, Takuya 著作を一覧する
Saito, Hiroshi 著作を一覧する
Ohguchi, Takeshi 著作を一覧する
Kijima, Riki 著作を一覧する
Chin, Shinki 著作を一覧する
Ishida, Susumu 著作を一覧する
キーワード: obstructive sleep apnea syndrome
intraocular pressure
contact lens sensor
episodic hypoxia
nocturnal sleep
発行日: 2016年 5月
出版者: Association for Research in Vision and Ophthalmology
誌名: Investigative ophthalmology & visual science
巻: 57
号: 6
開始ページ: 2824
終了ページ: 2830
出版社 DOI: 10.1167/iovs.16-19220
抄録: PURPOSE. To evaluate intraocular pressure (IOP) changes during nocturnal sleep in patients with obstructive sleep apnea syndrome (OSAS) using a contact lens sensor (CLS). METHODS. This was a prospective cohort study. Seven OSAS patients who had no ocular diseases except mild cataract were enrolled. Each subject underwent CLS-based continuous IOP monitoring on one eye simultaneously with overnight polysomnography. We classified the nocturnal IOP records into nonapnea IOP and apnea IOP, according to the duration of apnea events on polysomnography within each IOP measurement time of 30 seconds every 5 minutes. RESULTS. Differences between IOP levels during nonapnea and apnea phases were statistically analyzed. The mean apnea-hypopnea index, the total number of these events per hour of sleep, was 44.2 +/- 21.0, indicating the participants' severity of OSAS as moderate to severe. The mean range of IOP fluctuations during nocturnal sleep was 22.3 +/- 59.5 mV eq. All patients showed lower mean IOP levels during apnea events than during nonapnea phases, with statistically significant differences detected in four of the seven patients. On average, in all seven eyes, IOP values significantly decreased by 23.1 +/- 16.4 mV eq in association with apnea events. CONCLUSIONS. Obstructive apnea led to an immediate IOP decline during nocturnal sleep in patients with OSAS. Attention should be paid to IOP-independent etiology, such as episodic hypoxia, potentially linking OSAS and glaucoma.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 新明 康弘


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