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Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome

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Title: Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome
Authors: Shinmei, Yasuhiro Browse this author →KAKEN DB
Nitta, Takuya Browse this author
Saito, Hiroshi Browse this author
Ohguchi, Takeshi Browse this author
Kijima, Riki Browse this author
Chin, Shinki Browse this author →KAKEN DB
Ishida, Susumu Browse this author →KAKEN DB
Keywords: obstructive sleep apnea syndrome
intraocular pressure
glaucoma
contact lens sensor
episodic hypoxia
nocturnal sleep
Issue Date: May-2016
Publisher: Association for Research in Vision and Ophthalmology
Journal Title: Investigative ophthalmology & visual science
Volume: 57
Issue: 6
Start Page: 2824
End Page: 2830
Publisher DOI: 10.1167/iovs.16-19220
PMID: 27227351
Abstract: PURPOSE. To evaluate intraocular pressure (IOP) changes during nocturnal sleep in patients with obstructive sleep apnea syndrome (OSAS) using a contact lens sensor (CLS). METHODS. This was a prospective cohort study. Seven OSAS patients who had no ocular diseases except mild cataract were enrolled. Each subject underwent CLS-based continuous IOP monitoring on one eye simultaneously with overnight polysomnography. We classified the nocturnal IOP records into nonapnea IOP and apnea IOP, according to the duration of apnea events on polysomnography within each IOP measurement time of 30 seconds every 5 minutes. RESULTS. Differences between IOP levels during nonapnea and apnea phases were statistically analyzed. The mean apnea-hypopnea index, the total number of these events per hour of sleep, was 44.2 +/- 21.0, indicating the participants' severity of OSAS as moderate to severe. The mean range of IOP fluctuations during nocturnal sleep was 22.3 +/- 59.5 mV eq. All patients showed lower mean IOP levels during apnea events than during nonapnea phases, with statistically significant differences detected in four of the seven patients. On average, in all seven eyes, IOP values significantly decreased by 23.1 +/- 16.4 mV eq in association with apnea events. CONCLUSIONS. Obstructive apnea led to an immediate IOP decline during nocturnal sleep in patients with OSAS. Attention should be paid to IOP-independent etiology, such as episodic hypoxia, potentially linking OSAS and glaucoma.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/62626
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 新明 康弘

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