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Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice : a prospective cohort studya prospective cohort study

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Title: Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice : a prospective cohort studya prospective cohort study
Authors: Kubo, Kimitoshi Browse this author
Kawakami, Hiroshi Browse this author →KAKEN DB
Kuwatani, Masaki Browse this author →KAKEN DB
Nishida, Mutsumi Browse this author →KAKEN DB
Kawakubo, Kazumichi Browse this author
Kawahata, Shuhei Browse this author
Taya, Yoko Browse this author
Kubota, Yoshimasa Browse this author
Amano, Toraji Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Liver Elasticity
Obstructive jaundice
Biliary drainage
Transient elastography
Virtual Touch (TM) Quantification
Liver fibrosis
Hyaluronic acid
Issue Date: 8-Jul-2016
Publisher: BioMed Central
Journal Title: BMC gastroenterology
Volume: 16
Start Page: 65
Publisher DOI: 10.1186/s12876-016-0479-3
Abstract: Background: Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. The aim of our prospective study was to evaluate the changes in liver elasticity, before and after biliary drainage, in patients with obstructive jaundice, and to evaluate the correlation between elasticity measures and serum markers of liver fibrosis. Methods: This is a prospective cohort study of 20 patients with obstructive jaundice. Liver elasticity was assessed by Transient Elastography (TE) and Virtual Touch (TM) Quantification (VTQ). Serum total bilirubin (T-Bil) level was measured before biliary drainage (Day 0), with measures repeated at 2 days (Day 2) and 7 days (Day 7) after biliary drainage. Serum levels of the following markers of liver fibrosis were also obtained on Day 0 and Day 7: hyaluronic acid (HA), procollagen-III-peptide (P-III-P). Results: T-Bil, TE, and VTQ for the left (VTQ-L) and right (VTQ-R) lobes of the liver were all elevated before biliary drainage, with respective levels, measured at Day 0, of 11.9 +/- 1.5 mg/dl, 12.1 +/- 0.9 kPa, 2.23 +/- 0.10 m/s, and 1.85 +/- 0. 10 m/s. All values decreased on Day 7 after drainage: T-Bil, 4.7 +/- 1.0 mg/dl (P < 0.001); TE, 7.6 +/- 0.6 kPa (P < 0.001); VTQ-L, 1.53 +/- 0.08 m/s (P < 0.001); and VTQ-R, 1.30 +/- 0.05 m/s (P < 0.001). Similar changes were observed in serum markers of liver fibrosis. Liver elasticity measures correlated with serum levels of T-Bil, P-III-P, and HA (r = 0.35-0.67, P < 0.001). Conclusions: This study confirmed decreases in liver elasticity, measured by TE and VTQ, after biliary drainage. Measures of liver elasticity correlated to levels of T-Bil and serum markers of liver fibrosis. (UMIN ID: UMIN00001284313).
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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