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Simultaneous Tc-99m and I-123 dual-radionuclide imaging with a solid-state detector-based brain-SPECT system and energy-based scatter correction
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| Title: | Simultaneous Tc-99m and I-123 dual-radionuclide imaging with a solid-state detector-based brain-SPECT system and energy-based scatter correction |
| Authors: | Takeuchi, Wataru Browse this author | | Suzuki, Atsuro Browse this author | | Shiga, Tohru Browse this author →KAKEN DB | | Kubo, Naoki Browse this author →KAKEN DB | | Morimoto, Yuichi Browse this author | | Ueno, Yuichiro Browse this author | | Kobashi, Keiji Browse this author | | Umegaki, Kikuo Browse this author | | Tamaki, Nagara Browse this author →KAKEN DB |
| Keywords: | Dual radionuclide | | Solid-state detector | | CdTe | | Scatter correction | | Crosstalk |
| Issue Date: | 29-Jun-2016 |
| Publisher: | Springer |
| Journal Title: | EJNMMI physics |
| Volume: | 3 |
| Start Page: | 10 |
| Publisher DOI: | 10.1186/s40658-016-0147-2 |
| Abstract: | Background: A brain single-photon emission computed tomography (SPECT) system using cadmium telluride (CdTe) solid-state detectors was previously developed. This CdTe-SPECT system is suitable for simultaneous dual-radionuclide imaging due to its fine energy resolution (6.6 %). However, the problems of down-scatter and low-energy tail due to the spectral characteristics of a pixelated solid-state detector should be addressed. The objective of this work was to develop a system for simultaneous Tc-99m and I-123 brain studies and evaluate its accuracy. Methods: A scatter correction method using five energy windows (FiveEWs) was developed. The windows are Tc-lower, Tc-main, shared sub-window of Tc-upper and I-lower, I-main, and I-upper. This FiveEW method uses pre-measured responses for primary gamma rays from each radionuclide to compensate for the overestimation of scatter by the triple-energy window method that is used. Two phantom experiments and a healthy volunteer experiment were conducted using the CdTe-SPECT system. A cylindrical phantom and a six-compartment phantom with five different mixtures of Tc-99m and I-123 and a cold one were scanned. The quantitative accuracy was evaluated using 18 regions of interest for each phantom. In the volunteer study, five healthy volunteers were injected with Tc-99m human serum albumin diethylene triamine pentaacetic acid (HSA-D) and scanned (single acquisition). They were then injected with I-123 N-isopropyl-4-iodoamphetamine hydrochloride (IMP) and scanned again (dual acquisition). The counts of the Tc-99m images for the single and dual acquisitions were compared. Results: In the cylindrical phantom experiments, the percentage difference (PD) between the single and dual acquisitions was 5.7 +/- 4.0 % (mean +/- standard deviation). In the six-compartment phantom experiment, the PDs between measured and injected activity for Tc-99m and I-123 were 14.4 +/- 11.0 and 2.3 +/- 1.8 %, respectively. In the volunteer study, the PD between the single and dual acquisitions was 4.5 +/- 3.4 %. Conclusions: This CdTe-SPECT system using the FiveEW method can provide accurate simultaneous dual-radionuclide imaging. A solid-state detector SPECT system using the FiveEW method will permit quantitative simultaneous Tc-99m and I-123 study to become clinically applicable. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/62692 |
| Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 玉木 長良
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