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Platelet aggregation in citrated whole blood of the first trimester of pregnancy

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タイトル: Platelet aggregation in citrated whole blood of the first trimester of pregnancy
著者: Umazume, Takeshi 著作を一覧する
Yamada, Takahiro 著作を一覧する
Morikawa, Mamoru 著作を一覧する
Ishikawa, Satoshi 著作を一覧する
Furuta, Itsuko 著作を一覧する
Koyama, Takahiro 著作を一覧する
Matsuno, Kazuhiko 著作を一覧する
Minakami, Hisanori 著作を一覧する
キーワード: Mean platelet volume
Platelet reactivity
Pregnancy
Spontaneous platelet aggregation
Venous thromboembolism
発行日: 2015年 8月25日
出版者: Elsevier
誌名: Clinica chimica acta
巻: 448
開始ページ: 60
終了ページ: 64
出版社 DOI: 10.1016/j.cca.2015.06.011
抄録: Background: It was recently suggested that platelet reactivity is reduced in early pregnancy. This study was performed to determine whether the citrated whole blood from 33 pregnant women in their first trimester showed spontaneous platelet aggregation and whether it differed in extent from that of 11 non-pregnant women. Methods: The platelet count and number of platelet aggregates (PA) were serially determined in the same citrated whole blood specimens at 15, 30, 45, 60, 75, and 90 min after blood sampling using a hematology analyzer. Results: The number of PA increased significantly at 30 min and thereafter in both groups, but was consistently lower for pregnant than non-pregnant women over the 90-min observation period. The platelet count decreased significantly in a time-dependent manner in both groups, but was significantly lower at 30 and 90 min for nonpregnant than pregnant women. The number of PA showed a significant positive correlation with net decrease in platelet count for both pregnant and non-pregnant women. PA counts were also significantly positively correlated with the mean platelet volume. Conclusion: Platelet reactivity monitored by the increase in number of PA and the fall in platelet count was reduced in early pregnancy compared with non-pregnant healthy controls.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/62705
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 山田 崇弘

 

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