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Platelet aggregation in citrated whole blood of the first trimester of pregnancy

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Title: Platelet aggregation in citrated whole blood of the first trimester of pregnancy
Authors: Umazume, Takeshi Browse this author →KAKEN DB
Yamada, Takahiro Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Ishikawa, Satoshi Browse this author
Furuta, Itsuko Browse this author →KAKEN DB
Koyama, Takahiro Browse this author
Matsuno, Kazuhiko Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: Mean platelet volume
Platelet reactivity
Pregnancy
Spontaneous platelet aggregation
Venous thromboembolism
Issue Date: 25-Aug-2015
Publisher: Elsevier
Journal Title: Clinica chimica acta
Volume: 448
Start Page: 60
End Page: 64
Publisher DOI: 10.1016/j.cca.2015.06.011
PMID: 26102281
Abstract: Background: It was recently suggested that platelet reactivity is reduced in early pregnancy. This study was performed to determine whether the citrated whole blood from 33 pregnant women in their first trimester showed spontaneous platelet aggregation and whether it differed in extent from that of 11 non-pregnant women. Methods: The platelet count and number of platelet aggregates (PA) were serially determined in the same citrated whole blood specimens at 15, 30, 45, 60, 75, and 90 min after blood sampling using a hematology analyzer. Results: The number of PA increased significantly at 30 min and thereafter in both groups, but was consistently lower for pregnant than non-pregnant women over the 90-min observation period. The platelet count decreased significantly in a time-dependent manner in both groups, but was significantly lower at 30 and 90 min for nonpregnant than pregnant women. The number of PA showed a significant positive correlation with net decrease in platelet count for both pregnant and non-pregnant women. PA counts were also significantly positively correlated with the mean platelet volume. Conclusion: Platelet reactivity monitored by the increase in number of PA and the fall in platelet count was reduced in early pregnancy compared with non-pregnant healthy controls.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62705
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

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