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Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro

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Title: Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro
Authors: Endo, Shogo Browse this author
Kudo, Nobuki Browse this author →KAKEN DB
Yamaguchi, Shigeru Browse this author
Sumiyoshi, Koki Browse this author
Motegi, Hiroaki Browse this author
Kobayashi, Hiroyuki Browse this author
Terasaka, Shunsuke Browse this author →KAKEN DB
Houkin, Kiyohiro Browse this author →KAKEN DB
Keywords: 5-Aminolevulinic acid
In vitro
Malignant glioma
Porphyrin derivatives
Protoporphyrin IX
Sonodynamic therapy
Talaporfin sodium
Issue Date: Sep-2015
Publisher: Elsevier
Journal Title: Ultrasound in medicine and biology
Volume: 41
Issue: 9
Start Page: 2458
End Page: 2465
Publisher DOI: 10.1016/j.ultrasmedbio.2015.05.007
PMID: 26071619
Abstract: Because it is highly infiltrative, malignant glioma is a cancer with a poor prognosis despite multidisciplinary treatment strategies, such as aggressive surgery and chemoradiotherapy, necessitating new therapeutic approaches to control migration of tumor cells. In our study, we investigated the efficacy of sonodynamic therapy of glioma cells in vitro using porphyrin derivatives, including 5-aminolevulinic acid, protoporphyrin IX and talaporfin sodium, as sonosensitizers. These substances have been known to accumulate in glioma cells and are expected to have cytotoxic effects on sonication. Our study found that the cytotoxicity of sonication of glioma cells is enhanced by each sonosensitizer and that the efficacy of sonodynamic therapy may depend on the degree of intracellular accumulation of sonosensitizer. Also, the study suggests that induction of apoptosis is a major mechanism underlying cell death. Though further investigations are necessary, our preliminary result indicates a potential for sonodynamic therapy with sonosensitizers in glioma treatment.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 遠藤 将吾

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