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Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro
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| Title: | Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro |
| Authors: | Endo, Shogo Browse this author | | Kudo, Nobuki Browse this author →KAKEN DB | | Yamaguchi, Shigeru Browse this author | | Sumiyoshi, Koki Browse this author | | Motegi, Hiroaki Browse this author | | Kobayashi, Hiroyuki Browse this author | | Terasaka, Shunsuke Browse this author →KAKEN DB | | Houkin, Kiyohiro Browse this author →KAKEN DB |
| Keywords: | 5-Aminolevulinic acid | | In vitro | | Malignant glioma | | Porphyrin derivatives | | Protoporphyrin IX | | Sonodynamic therapy | | Talaporfin sodium | | Ultrasound |
| Issue Date: | Sep-2015 |
| Publisher: | Elsevier |
| Journal Title: | Ultrasound in medicine and biology |
| Volume: | 41 |
| Issue: | 9 |
| Start Page: | 2458 |
| End Page: | 2465 |
| Publisher DOI: | 10.1016/j.ultrasmedbio.2015.05.007 |
| PMID: | 26071619 |
| Abstract: | Because it is highly infiltrative, malignant glioma is a cancer with a poor prognosis despite multidisciplinary treatment strategies, such as aggressive surgery and chemoradiotherapy, necessitating new therapeutic approaches to control migration of tumor cells. In our study, we investigated the efficacy of sonodynamic therapy of glioma cells in vitro using porphyrin derivatives, including 5-aminolevulinic acid, protoporphyrin IX and talaporfin sodium, as sonosensitizers. These substances have been known to accumulate in glioma cells and are expected to have cytotoxic effects on sonication. Our study found that the cytotoxicity of sonication of glioma cells is enhanced by each sonosensitizer and that the efficacy of sonodynamic therapy may depend on the degree of intracellular accumulation of sonosensitizer. Also, the study suggests that induction of apoptosis is a major mechanism underlying cell death. Though further investigations are necessary, our preliminary result indicates a potential for sonodynamic therapy with sonosensitizers in glioma treatment. |
| Rights: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62735 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 遠藤 将吾
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