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Role of the Atg9a gene in intrauterine growth and survival of fetal mice

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Title: Role of the Atg9a gene in intrauterine growth and survival of fetal mice
Other Titles: Atg9a gene in murine fetal growth and survival
Authors: Kojima, Takashi Browse this author
Yamada, Takahiro Browse this author →KAKEN DB
Akaishi, Rina Browse this author
Furuta, Itsuko Browse this author →KAKEN DB
Saitoh, Tatsuya Browse this author →KAKEN DB
Nakabayashi, Kazuhiko Browse this author →KAKEN DB
Nakayama, Keiichi I. Browse this author →KAKEN DB
Nakayama, Keiko Browse this author →KAKEN DB
Akira, Shizuo Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: Autophagy
Fetal growth restriction
Hypoxia
Intrauterine fetal death
Hypertension
Issue Date: Sep-2015
Publisher: Elsevier
Journal Title: Reproductive biology
Volume: 15
Issue: 3
Start Page: 131
End Page: 138
Publisher DOI: 10.1016/j.repbio.2015.05.001
PMID: 26370455
Abstract: Autophagy is activated by environment unfavorable for survival and requires Atg9a protein. Mice heterozygous for p57(KiP2), devoid of the imprinted paternal allele (p57(KiP2+/-)), are known to develop hypertension during pregnancy. To determine whether fetal Atg9a is involved in the intrauterine survival and growth of fetal mice, this study was performed on Atg9a heterozygous (Atg9a(+/-)) pregnant mice with and without p57(KiP2+/-). The pregnant mice heterozygous for both knockout alleles of Atg9a and p57(KiP2) (Atg9a(+/-)/p57(KiP2+/-)), but not those heterozygous for Atg9a alone, developed hypertension during pregnancy. Placental expression of Atg9a mRNA was significantly decreased in the Atg9a(-/-) mice compared to Atg9a(+/-) or Atg9a(+/+) mice. The Atg9a(-/-) fetal mice exhibited significantly retarded growth and were more likely to die in utero compared to Atg9a(+/+) and Atg9a(+/-) fetal mice. Growth retardation was observed in the presence of maternal hypertension in Atg9a(-/-) fetal mice. These results suggest that Atg9a(-/-) fetal mice from pregnant dams heterozygous for both knockout alleles of Atg9a and p57(KiP2) are more susceptible to hypertensive stress than fetuses with intact autophagic machinery.
Rights: © 2015. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/62736
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

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