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The cardiac blood supply-workload balance in children

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/62738

Title: The cardiac blood supply-workload balance in children
Authors: Murakami, Tomoaki Browse this author
Takeda, Atsuhito Browse this author →KAKEN DB
Takei, Kohta Browse this author
Tateno, Shigeru Browse this author
Kawasoe, Yasutaka Browse this author
Niwa, Koichiro Browse this author
Keywords: Aging
Growth
Aortic function
Central hemodynamics
Issue Date: Sep-2015
Publisher: Springer
Journal Title: Heart and vessels
Volume: 30
Issue: 5
Start Page: 626
End Page: 631
Publisher DOI: 10.1007/s00380-014-0537-0
PMID: 24989969
Abstract: It is well known that the reflected pressure wave in small children returns earlier than that in adolescent. The reason of early return of the reflected pressure wave in infancy is their height. The short distance between heart and reflection point makes the reflected pressure wave returning to the heart earlier. In adult, the early return (during systole) of the reflected pressure wave means disadvantage to cardiac blood supply-workload balance. The purpose of this study was to clarify whether the early return of the reflected pressure wave in small children impairs the cardiac blood supply-workload balance. This study enrolled 37 small left-to-right shunt patients with normal aortic circulation below 15 years of age. The aortic pressure waveform was recorded using a pressure sensor mounted catheter, and augmentation index and subendocardial viability ratio were calculated. The age of patients was 6.1 ± 3.2 years. The augmentation index was 8.7 ± 14.3 % and the index had a negative correlation with patients' age (r = -0.6243, p < 0.0001). The subendocardial viability ratio, which means the cardiac blood supply-workload balance, was 0.92 ± 0.14 and the index had a positive relationship with patients' age (r = 0.6435, p < 0.0001). The cardiac blood supply-workload balance gradually improves from infancy to young adulthood. One of the causes of the unfavorable cardiac blood supply-workload balance in infancy would be the accelerated aortic pressure wave reflection due to their short height.
Rights: The final publication is available at Springer via http://dx.doi.org/10.1007/s00380-014-0537-0
Type: article (author version)
URI: http://hdl.handle.net/2115/62738
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 武田 充人

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