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MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease

Autoimmunity48(6)p.402_Fig.1-8.pdf2.68 MBPDF見る/開く

タイトル: MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease
著者: Otani, Yuki 著作を一覧する
Ichii, Osamu 著作を一覧する
Otsuka-Kanazawa, Saori 著作を一覧する
Chihara, Masataka 著作を一覧する
Nakamura, Teppei 著作を一覧する
Kon, Yasuhiro 著作を一覧する
キーワード: MRL/lpr mice
autoimmune disease
estrous cycle
ovarian reserve
発行日: 2015年 9月
出版者: Taylor & Francis
誌名: Autoimmunity
巻: 48
号: 6
開始ページ: 402
終了ページ: 411
出版社 DOI: 10.3109/08916934.2015.1031889
抄録: The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmune disease-prone MRL/MpJ (MRL/+) mice and congenic MRL/MpJ-Fas(lpr) (MRL/lpr) mice harboring a mutation in the Fas gene that speeds disease onset. Both MRL-background strains showed earlier vaginal opening than C57BL/6 mice. The estrous cycle became irregular by 6 and 12 months of age in MRL/lpr mice and mice of the other two strains, respectively. Histological analysis at 3 months revealed that the number of primordial follicles was smaller in MRL-background mice than in C57BL/6 mice after 3 months. In addition, MRL/lpr and MRL/+ mice displayed lower numbers of ovarian follicles and corpora lutea at 3 and 6 months, and 6 and 12 months, respectively, than that in age-matched C57BL/6 mice. MRL/lpr and MRL/+ mice developed ovarian interstitial glands after 3 and 6 months, respectively. In particular, MRL/lpr mice showed numerous infiltrating lymphocytes within the ovarian interstitia, and partially stratified ovarian surface epithelia with more developed microvilli than that observed in C57BL/6 mice at 6 months. No significant differences in serum hormone levels were observed between the strains. In conclusion, MRL/lpr mice display altered ovarian development, morphology and function consistent with the progression of severe autoimmune disease, as these findings are less severe in MRL/+ counterparts.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in 'Autoimmunity' on 2015-08-27, available online:
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 昆 泰寛


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