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MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease
Title: | MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease |
Authors: | Otani, Yuki Browse this author | Ichii, Osamu Browse this author →KAKEN DB | Otsuka-Kanazawa, Saori Browse this author →KAKEN DB | Chihara, Masataka Browse this author | Nakamura, Teppei Browse this author | Kon, Yasuhiro Browse this author →KAKEN DB |
Keywords: | MRL/lpr mice | autoimmune disease | ovary | estrous cycle | ovarian reserve |
Issue Date: | Sep-2015 |
Publisher: | Taylor & Francis |
Journal Title: | Autoimmunity |
Volume: | 48 |
Issue: | 6 |
Start Page: | 402 |
End Page: | 411 |
Publisher DOI: | 10.3109/08916934.2015.1031889 |
PMID: | 25857350 |
Abstract: | The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmune disease-prone MRL/MpJ (MRL/+) mice and congenic MRL/MpJ-Fas(lpr) (MRL/lpr) mice harboring a mutation in the Fas gene that speeds disease onset. Both MRL-background strains showed earlier vaginal opening than C57BL/6 mice. The estrous cycle became irregular by 6 and 12 months of age in MRL/lpr mice and mice of the other two strains, respectively. Histological analysis at 3 months revealed that the number of primordial follicles was smaller in MRL-background mice than in C57BL/6 mice after 3 months. In addition, MRL/lpr and MRL/+ mice displayed lower numbers of ovarian follicles and corpora lutea at 3 and 6 months, and 6 and 12 months, respectively, than that in age-matched C57BL/6 mice. MRL/lpr and MRL/+ mice developed ovarian interstitial glands after 3 and 6 months, respectively. In particular, MRL/lpr mice showed numerous infiltrating lymphocytes within the ovarian interstitia, and partially stratified ovarian surface epithelia with more developed microvilli than that observed in C57BL/6 mice at 6 months. No significant differences in serum hormone levels were observed between the strains. In conclusion, MRL/lpr mice display altered ovarian development, morphology and function consistent with the progression of severe autoimmune disease, as these findings are less severe in MRL/+ counterparts. |
Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in 'Autoimmunity' on 2015-08-27, available online: http://www.tandfonline.com/10.3109/08916934.2015.1031889 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/62751 |
Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 昆 泰寛
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