HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
北海道大学病院  >
雑誌発表論文等  >

Effects of prehospital epinephrine administration on neurological outcomes in patients with out-of-hospital cardiac arrest

この資料はクリエイティブ・コモンズ・ライセンスの下で公開されています。

フルテキスト
art_10.1186_s40560-015-0094-3.pdf618.23 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/62779

タイトル: Effects of prehospital epinephrine administration on neurological outcomes in patients with out-of-hospital cardiac arrest
著者: Ono, Yuichi 著作を一覧する
Hayakawa, Mineji 著作を一覧する
Wada, Takeshi 著作を一覧する
Sawamura, Atsushi 著作を一覧する
Gando, Satoshi 著作を一覧する
キーワード: Out-of-hospital cardiac arrest
Resuscitation
Epinephrine
Prehospital
発行日: 2015年 6月24日
出版者: BioMed Central
誌名: Journal of Intensive Care
巻: 3
開始ページ: 29
出版社 DOI: 10.1186/s40560-015-0094-3
抄録: Background: To determine if the effects of epinephrine administration on the outcome of out-of-hospital cardiac arrest (OHCA), patients are associated with the duration of cardiopulmonary resuscitation (CPR) performed by Emergency Medical Service (EMS) personnel. Methods: This retrospective, nonrandomized, observational analysis used the All-Japan Utstein Registry, a prospective, nationwide population-based registry of all OHCA patients transported to the hospital by EMS staff as the data source. We stratified all OHCA patients for quartile of EMSs' CPR duration. Group 1 consisted of patients who fell under the 25th percentile of EMSs' CPR duration (under 15 min); group 2, patients who fell into the 25th to 50th percentile (between 15 and 19 min); group 3, patients who fell into the 50th to 75th percentile (between 20 and 26 min); and group 4, patients who fell at or above the 75th percentile (over 26 min). The primary endpoint was a favorable neurological outcome 1 month after cardiac arrest. The secondary endpoints were ROSC before arrival at the hospital and 1-month survival. Results: A total of 383,811 patients aged over 18 years who had experienced OHCA between 2006 and 2010 in Japan, when stratified for quartile of EMSs' CPR duration, the epinephrine administration increased the rate of return of spontaneous circulation (ROSC) approximately tenfold in all groups. However, the beneficial effects of epinephrine administration on 1-month survival disappeared in patients on whom EMSs' CPR had been performed for more than 26 min, and the beneficial effects of epinephrine administration on neurological outcomes were observed only in patients on whom EMSs' CPR had been performed between 15 and 19 min (odds ratio, 1.327, 95 % confidence intervals, 1.017-1.733 P = 0.037). Conclusions: Epinephrine administration is associated with an increase of ROSC and with improvement in the neurological outcome on which EMSs' CPR duration is performed between 15 and 19 min.
資料タイプ: article
URI: http://hdl.handle.net/2115/62779
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 早川 峰司

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学