| Title: | A Retrospective Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Adult T Cell Leukemia/Lymphoma (ATL) : Clinical Impact of Graft-versus-Leukemia/Lymphoma Effect |
| Authors: | Shiratori, Souichi Browse this author →KAKEN DB |
| Yasumoto, Atsushi Browse this author |
| Tanaka, Junji Browse this author →KAKEN DB |
| Shigematsu, Akio Browse this author →KAKEN DB |
| Yamamoto, Satoshi Browse this author |
| Nishio, Mitsufumi Browse this author →KAKEN DB |
| Hashino, Satoshi Browse this author →KAKEN DB |
| Morita, Rena Browse this author |
| Takahata, Mutsumi Browse this author |
| Onozawa, Masahiro Browse this author →KAKEN DB |
| Kahata, Kaoru Browse this author |
| Kondo, Takeshi Browse this author →KAKEN DB |
| Ota, Shuichi Browse this author |
| Wakasa, Kentaro Browse this author |
| Sugita, Junichi Browse this author →KAKEN DB |
| Koike, Takao Browse this author →KAKEN DB |
| Asaka, Masahiro Browse this author →KAKEN DB |
| Kasai, Masaharu Browse this author |
| Imamura, Masahiro Browse this author →KAKEN DB |
| Keywords: | Adult T cell leukemia/lymphoma |
| Human T cell lymphotropic virus type 1 |
| Allogeneic stem cell transplantation |
| HTLV-1 proviral DNA |
| GVL effect |
| Issue Date: | Jul-2008 |
| Publisher: | Elsevier |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 14 |
| Issue: | 7 |
| Start Page: | 817 |
| End Page: | 823 |
| Publisher DOI: | 10.1016/j.bbmt.2008.04.014 |
| PMID: | 18541202 |
| Abstract: | Adult T cell leukemia/lymphoma (ATL) is a highly aggressive T cell malignancy, and has a poor prognosis. Recently, allogeneic-hematopoietic stem cell transplantation (allo-HSCT) has been suggested to improve the outcome. We retrospectively analyzed 15 patients with ATL who had received allo-HSCT in 2 institutions in Hokkaido, Japan. The median age of the patients was 57 years. The estimated 3-year overall survival (OS) and progression-free survival (PFS) rates were 73.3% and 66.7%, respectively. Calcineurin inhibitor dosage was reduced and administration was discontinued abruptly in 6 of the 15 patients for disease control; as a result, 4 (66.7%) of the 6 patients achieved complete response (CR) or partial response. Therefore, a graft-versus-leukemia/lymphoma (GVL) effect might be induced by discontinuation of immunosuppression. Thirteen of the 15 patients were followed up by monitoring HTLV-1 proviral DNA levels. In 10 of the 11 patients with positive HTLV-1 proviral DNA before allo-HSCT, HTLV-1 proviral DNA became undetectable at least once after allo-HSCT, and only 1 of the 5 patients in whom HTLV-1 proviral DNA became detectable after allo-HSCT relapsed. Compared to the results of past studies, these results show that allo-HSCT greatly improved the prognosis of ATL and suggest a contribution of the induction of a GVL effect. |
| Description: | Erratum is published in Biology of Blood and Marrow Transplantation, Volume 14, Issue 9, 2008, p.1079. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/62834 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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