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A Retrospective Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Adult T Cell Leukemia/Lymphoma (ATL) : Clinical Impact of Graft-versus-Leukemia/Lymphoma Effect

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Title: A Retrospective Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Adult T Cell Leukemia/Lymphoma (ATL) : Clinical Impact of Graft-versus-Leukemia/Lymphoma Effect
Authors: Shiratori, Souichi Browse this author →KAKEN DB
Yasumoto, Atsushi Browse this author
Tanaka, Junji Browse this author →KAKEN DB
Shigematsu, Akio Browse this author →KAKEN DB
Yamamoto, Satoshi Browse this author
Nishio, Mitsufumi Browse this author →KAKEN DB
Hashino, Satoshi Browse this author →KAKEN DB
Morita, Rena Browse this author
Takahata, Mutsumi Browse this author
Onozawa, Masahiro Browse this author →KAKEN DB
Kahata, Kaoru Browse this author
Kondo, Takeshi Browse this author →KAKEN DB
Ota, Shuichi Browse this author
Wakasa, Kentaro Browse this author
Sugita, Junichi Browse this author →KAKEN DB
Koike, Takao Browse this author →KAKEN DB
Asaka, Masahiro Browse this author →KAKEN DB
Kasai, Masaharu Browse this author
Imamura, Masahiro Browse this author →KAKEN DB
Keywords: Adult T cell leukemia/lymphoma
Human T cell lymphotropic virus type 1
Allogeneic stem cell transplantation
HTLV-1 proviral DNA
GVL effect
Issue Date: Jul-2008
Publisher: Elsevier
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 14
Issue: 7
Start Page: 817
End Page: 823
Publisher DOI: 10.1016/j.bbmt.2008.04.014
PMID: 18541202
Abstract: Adult T cell leukemia/lymphoma (ATL) is a highly aggressive T cell malignancy, and has a poor prognosis. Recently, allogeneic-hematopoietic stem cell transplantation (allo-HSCT) has been suggested to improve the outcome. We retrospectively analyzed 15 patients with ATL who had received allo-HSCT in 2 institutions in Hokkaido, Japan. The median age of the patients was 57 years. The estimated 3-year overall survival (OS) and progression-free survival (PFS) rates were 73.3% and 66.7%, respectively. Calcineurin inhibitor dosage was reduced and administration was discontinued abruptly in 6 of the 15 patients for disease control; as a result, 4 (66.7%) of the 6 patients achieved complete response (CR) or partial response. Therefore, a graft-versus-leukemia/lymphoma (GVL) effect might be induced by discontinuation of immunosuppression. Thirteen of the 15 patients were followed up by monitoring HTLV-1 proviral DNA levels. In 10 of the 11 patients with positive HTLV-1 proviral DNA before allo-HSCT, HTLV-1 proviral DNA became undetectable at least once after allo-HSCT, and only 1 of the 5 patients in whom HTLV-1 proviral DNA became detectable after allo-HSCT relapsed. Compared to the results of past studies, these results show that allo-HSCT greatly improved the prognosis of ATL and suggest a contribution of the induction of a GVL effect.
Description: Erratum is published in Biology of Blood and Marrow Transplantation, Volume 14, Issue 9, 2008, p.1079.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/62834
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小池 隆夫

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