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Perilipin overexpression in mice protects against diet-induced obesity

58_J.LipidRes.-2010-Miyoshi-975-82.pdf1.12 MBPDF見る/開く

タイトル: Perilipin overexpression in mice protects against diet-induced obesity
著者: Miyoshi, Hideaki 著作を一覧する
Souza, Sandra C. 著作を一覧する
Endo, Mikiko 著作を一覧する
Sawada, Takashi 著作を一覧する
Perfield, James W. II 著作を一覧する
Shimizu, Chikara 著作を一覧する
Stancheva, Zlatina 著作を一覧する
Nagai, So 著作を一覧する
Strissel, Katherine J. 著作を一覧する
Yoshioka, Narihito 著作を一覧する
Obin, Martin S. 著作を一覧する
Koike, Takao 著作を一覧する
Greenberg, Andrew S. 著作を一覧する
キーワード: adipocyte
transgenic mice
lipid oxidation
glucose tolerance
insulin resistance
発行日: 2010年 5月
出版者: American Society for Biochemistry and Molecular Biology
誌名: Journal of Lipid Research
巻: 51
号: 5
開始ページ: 975
終了ページ: 982
出版社 DOI: 10.1194/jlr.M002352
抄録: Perilipin A is the most abundant phosphoprotein on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Perilipin null mice exhibit diminished adipose tissue, elevated basal lipolysis, reduced catecholamine-stimulated lipolysis, and increased insulin resistance. To understand the physiological consequences of increased perilipin expression in vivo, we generated transgenic mice that overexpressed either human or mouse perilipin using the adipocyte-specific aP2 promoter/enhancer. Phenotypes of female transgenic and wild-type mice were characterized on chow and high-fat diets (HFDs). When challenged with an HFD, transgenic mice exhibited lower body weight, fat mass, and adipocyte size than wild-type mice. Expression of oxidative genes was increased and lipogenic genes decreased in brown adipose tissue of transgenic mice. Basal and catecholamine-stimulated lipolysis was decreased and glucose tolerance significantly improved in transgenic mice fed a HFD. Perilipin overexpression in adipose tissue protects against HFD-induced adipocyte hypertrophy, obesity, and glucose intolerance. Alterations in brown adipose tissue metabolism may mediate the effects of perilipin overexpression on body fat, although the mechanisms by which perilipin overexpression alters brown adipose tissue metabolism remain to be determined. Our findings demonstrate a novel role for perilipin expression in adipose tissue metabolism and regulation of obesity and its metabolic complications.
Rights: This research was originally published in Journal of Lipid Research. Miyoshi, H., S. C. Souza, M. Endo, T. Sawada, J. W. Perfi eld II, C. Shimizu, Z. Stancheva, S. Nagai, K. J. Strissel, N. Yoshioka, M. S. Obin, T. Koike, and A. S. Greenberg. Perilipin overexpression in mice protects against diet-induced obesity. J. Lipid Res. 2010. 51: 975–982. © the American Society for Biochemistry and Molecular Biology.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 小池 隆夫


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