TRIM29 regulates the p63-mediated pathway in cervical cancer cells

Masuda, Yasushi; Takahashi, Hidehisa; Hatakeyama, Shigetsugu

doi:10.1016/j.bbamcr.2015.05.035


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TRIM29 regulates the p63-mediated pathway in cervical cancer cells

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Title:	TRIM29 regulates the p63-mediated pathway in cervical cancer cells
Authors:	Masuda, Yasushi Browse this author
	Takahashi, Hidehisa Browse this author →KAKEN DB
	Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords:	TRIM29
	Cell adhesion
	Cervical cancer
	p63
	Integrin
Issue Date:	Oct-2015
Publisher:	Elsevier
Journal Title:	Biochimica et Biophysica Acta. Molecular Cell Research
Volume:	1853
Issue:	10A
Start Page:	2296
End Page:	2305
Publisher DOI:	10.1016/j.bbamcr.2015.05.035
PMID:	26071105
Abstract:	Cell invasion and adhesion play an important role in cancer metastasis and are orchestrated by a complicated network of transcription factors including p63. Here, we show that a member of the tripartite motif protein family, TRIM29, is required for regulation of the p63-mediated pathway in cervical cancer cells. TRIM29 knockdown alters the adhesion and invasion activities of cervical cancer cells. TRIM29 knockdown and overexpression cause a significant decrease and increase of TAp63 alpha expression, respectively. TRIM29 knockdown alters the expression pattern of integrins and increases ZEB1 expression. TRIM29 is required for suppression of an increase in the adhesion activity of cells by TAp63 alpha. These findings suggest that TRIM29 regulates the p63-mediated pathway and the behavior of cervical cancer cells.
Rights:	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Rights:	https://creativecommons.org/licenses/by-nc-nd/4.0/
Type:	article (author version)
URI:	http://hdl.handle.net/2115/62917
Appears in Collections:	医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山鎮次

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