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Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus : A single institution experience

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Title: Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus : A single institution experience
Authors: Homma, Akihiro Browse this author →KAKEN DB
Nakamaru, Yuji Browse this author →KAKEN DB
Sakashita, Tomohiro Browse this author →KAKEN DB
Onimaru, Rikiya Browse this author →KAKEN DB
Terasaka, Shunsuke Browse this author →KAKEN DB
Tsuchiya, Kazuhiko Browse this author →KAKEN DB
Yoshida, Daisuke Browse this author
Yasuda, Koichi Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Furusawa, Jun Browse this author
Mizumachi, Takatsugu Browse this author →KAKEN DB
Kano, Satoshi Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Nasal cavity
Ethmoid sinus
Squamous cell carcinoma
Radiation therapy
Issue Date: Oct-2015
Publisher: Elsevier
Journal Title: Auris nasus larynx
Volume: 42
Issue: 5
Start Page: 377
End Page: 381
Publisher DOI: 10.1016/j.anl.2015.02.005
PMID: 25748513
Abstract: Objective: Here we report our experience of patients with squamous cell carcinoma (SCC) of the nasal cavity and ethmoid sinus (NC&ES) together with an analysis of treatment outcomes. Methods: A retrospective analysis was performed using data from 25 consecutive patients treated between 2000 and 2012. Four patients were diagnosed with T1, 3 with T2, 4 with T3, 7 with T4a, and 7 with T4b disease. No patient had lymph node metastasis. Results: Twelve patients were treated with surgery with/without radiotherapy and with/without chemotherapy. Of these, 4 underwent endoscopic surgery without an open approach and 3 required an anterior skull base approach. Thirteen were treated with radiotherapy; 1 with radiotherapy alone, and 4 and 8 with intravenous and intra-arterial chemotherapy, respectively. The 5-yr overall survival for T1-3, T4a, and T4b disease was 53.9%, 71.4%, and 29.0%, respectively. The 5-yr disease-specific survival for T1-3, T4a, and T4b disease was 74.1%, 71.4%, and 29.0%, respectively. Conclusion: Our treatment policy for patients with SCC of NC&ES, which basically follows the NCCN guideline, was considered to be appropriate. However, several points in terms of surgery and nonsurgical approach remain to be solved through further research.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 本間 明宏

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