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Intrapartum risk factors for neonatal encephalopathy leading to cerebral palsy in women without apparent sentinel events

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/62920

Title: Intrapartum risk factors for neonatal encephalopathy leading to cerebral palsy in women without apparent sentinel events
Authors: Yamada, Takahiro Browse this author →KAKEN DB
Cho, Kazutoshi Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Yamada, Takashi Browse this author →KAKEN DB
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: fetal heart rate tracing
instrumental delivery
macrosomia
non-reassuring fetal status
shoulder dystocia
vacuum delivery
Issue Date: Oct-2015
Publisher: Wiley-Blackwell
Journal Title: Journal of obstetrics and gynaecology research
Volume: 41
Issue: 10
Start Page: 1520
End Page: 1525
Publisher DOI: 10.1111/jog.12772
PMID: 26178588
Abstract: Aim: To determine intrapartum factors associated with neonatal encephalopathy leading to cerebral palsy (NE-CP). Methods: A total of 70 NE-CP patients who fulfilled study criteria (cephalic singleton pregnancy with attempted vaginal delivery [AVD] at gestational week [GW] ≥36; intrapartum occurrence of non-reassuring fetal status without apparent cause following reassuring fetal status on admission; and development of NE-CP) were compared with 210 AVD controls who had 1- and 5-min Apgar score ≥8 matched for GW, maternal parity, and use of uterotonics. Suboptimal care was defined as delayed reaction due to misinterpretation of fetal heart rate (FHR) tracing, or inappropriate trial of instrumental delivery (TOID). Successful and failed TOID were defined as vaginal and cesarean delivery after TOID, respectively. The 210 controls were assumed not to have had suboptimal care. Results: The rates of successful (34% vs 12%) and failed TOID (11% vs 0.0%), cesarean section (34% vs 14%), suboptimal care (57% vs 0.0%), pregnancy-induced hypertension (11% vs 2.4%), birthweight ≥3800 g (8.6% vs 1.9%), subgaleal hemorrhage (16% vs 0.0%) were significantly higher in NE-CP patients than in controls. Selection with the stepwise method and logistic regression analysis identified four independent risk factors for NE-CP: suboptimal intrapartum care (OR, 2.21; 95%CI: 1.99-2.47), cesarean section (OR, 1.19; 95%CI: 1.08-1.31), successful TOID (OR, 1.14; 95%CI: 1.03-1.25), and hypertension (OR, 1.20; 95%CI: 1.01-1.42). Conclusions: Training programs for improved interpretation of FHR tracing and appropriate TOID are required to prevent NE-CP among healthy and mature fetuses in Japan.
Rights: This is the peer reviewed version of the following article: Yamada, T., Cho, K., Morikawa, M., Yamada, T., and Minakami, H. (2015) Intrapartum risk factors for neonatal encephalopathy leading to cerebral palsy in women without apparent sentinel events. J. Obstet. Gynaecol. Res., 41: 1520–1525., which has been published in final form at http://dx.doi.org/10.1111/jog.12772. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/62920
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

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