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Intrapartum risk factors for neonatal encephalopathy leading to cerebral palsy in women without apparent sentinel events
| Title: | Intrapartum risk factors for neonatal encephalopathy leading to cerebral palsy in women without apparent sentinel events |
| Authors: | Yamada, Takahiro Browse this author →KAKEN DB | | Cho, Kazutoshi Browse this author →KAKEN DB | | Morikawa, Mamoru Browse this author →KAKEN DB | | Yamada, Takashi Browse this author →KAKEN DB | | Minakami, Hisanori Browse this author →KAKEN DB |
| Keywords: | fetal heart rate tracing | | instrumental delivery | | macrosomia | | non-reassuring fetal status | | shoulder dystocia | | vacuum delivery |
| Issue Date: | Oct-2015 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Journal of obstetrics and gynaecology research |
| Volume: | 41 |
| Issue: | 10 |
| Start Page: | 1520 |
| End Page: | 1525 |
| Publisher DOI: | 10.1111/jog.12772 |
| PMID: | 26178588 |
| Abstract: | Aim: To determine intrapartum factors associated with neonatal encephalopathy leading to cerebral palsy (NE-CP). Methods: A total of 70 NE-CP patients who fulfilled study criteria (cephalic singleton pregnancy with attempted vaginal delivery [AVD] at gestational week [GW] ≥36; intrapartum occurrence of non-reassuring fetal status without apparent cause following reassuring fetal status on admission; and development of NE-CP) were compared with 210 AVD controls who had 1- and 5-min Apgar score ≥8 matched for GW, maternal parity, and use of uterotonics. Suboptimal care was defined as delayed reaction due to misinterpretation of fetal heart rate (FHR) tracing, or inappropriate trial of instrumental delivery (TOID). Successful and failed TOID were defined as vaginal and cesarean delivery after TOID, respectively. The 210 controls were assumed not to have had suboptimal care. Results: The rates of successful (34% vs 12%) and failed TOID (11% vs 0.0%), cesarean section (34% vs 14%), suboptimal care (57% vs 0.0%), pregnancy-induced hypertension (11% vs 2.4%), birthweight ≥3800 g (8.6% vs 1.9%), subgaleal hemorrhage (16% vs 0.0%) were significantly higher in NE-CP patients than in controls. Selection with the stepwise method and logistic regression analysis identified four independent risk factors for NE-CP: suboptimal intrapartum care (OR, 2.21; 95%CI: 1.99-2.47), cesarean section (OR, 1.19; 95%CI: 1.08-1.31), successful TOID (OR, 1.14; 95%CI: 1.03-1.25), and hypertension (OR, 1.20; 95%CI: 1.01-1.42). Conclusions: Training programs for improved interpretation of FHR tracing and appropriate TOID are required to prevent NE-CP among healthy and mature fetuses in Japan. |
| Rights: | This is the peer reviewed version of the following article: Yamada, T., Cho, K., Morikawa, M., Yamada, T., and Minakami, H. (2015) Intrapartum risk factors for neonatal encephalopathy leading to cerebral palsy in women without apparent sentinel events. J. Obstet. Gynaecol. Res., 41: 1520–1525., which has been published in final form at http://dx.doi.org/10.1111/jog.12772. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/62920 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 山田 崇弘
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