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Prospective risk of stillbirth in women with placental mesenchymal dysplasia

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Title: Prospective risk of stillbirth in women with placental mesenchymal dysplasia
Authors: Ishikawa, Satoshi Browse this author
Morikawa, Mamoru Browse this author →KAKEN DB
Yamada, Takahiro Browse this author →KAKEN DB
Akaishi, Rina Browse this author
Kaneuchi, Masanori Browse this author
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: antenatal diagnosis
molar pregnancy
perinatal mortality
prophylactic treatment
Issue Date: Oct-2015
Publisher: Wiley-Blackwell
Journal Title: Journal of obstetrics and gynaecology research
Volume: 41
Issue: 10
Start Page: 1562
End Page: 1568
Publisher DOI: 10.1111/jog.12757
PMID: 26177879
Abstract: Aim: The aim of this study was to provide better counsel to pregnant women with suspected placental mesenchymal dysplasia (PMD) regarding the risks of preterm birth and intrauterine fetal death. Material and Methods: We reviewed the outcomes of 109 PMD pregnancies with gestational week (GW) ≥ 24 abstracted from 63 reports in the English-language published reports, including two cases that we encountered recently. The prospective risk of stillbirth at GW N was defined as the number of women with stillbirth at GW ≥ N divided by the number of women giving birth at GW ≥ N. Results: A total of 32 (29.4%) women experienced stillbirth at a median GW of 31 (range, 24-38). Preterm birth (GW < 37) occurred in 52 (67.5%) of the 77 live-born infants. Only 25 (22.9%) women had full-term (GW ≥ 37) live-born infants. The prospective risks of stillbirth were 29.4% (32/109), 27.5% (25/91), 20.9% (14/67) and 13.0% (6/46) for women who reached GW 24(+0), 28(+0), 32(+0) and 36(+0) respectively. Conclusion: As women with PMD are at markedly elevated risk of intrauterine fetal death, early admission to the hospital and intensive monitoring of fetal status should be considered, although whether this policy improves outcome has not been validated.
Rights: This is the peer reviewed version of the following article: Ishikawa, S., Morikawa, M., Yamada, T., Akaishi, R., Kaneuchi, M., and Minakami, H. (2015) Prospective risk of stillbirth in women with placental mesenchymal dysplasia. J. Obstet. Gynaecol. Res., 41: 1562–1568., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

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