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The dynamics of mucosal-associated invariant T cells in multiple sclerosis

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Title: The dynamics of mucosal-associated invariant T cells in multiple sclerosis
Authors: Sugimoto, Chie Browse this author
Hirotani, Makoto Browse this author →KAKEN DB
Yoshikiyo, Kazunori Browse this author
Koshimizu, Uichi Browse this author
Wakao, Rika Browse this author
Horinouchi, Takahiro Browse this author →KAKEN DB
Mazaki, Yuichi Browse this author
Higashi, Tsunehiko Browse this author
Fukazawa, Toshiyuki Browse this author
Fujita, Hiroyoshi Browse this author →KAKEN DB
Sasaki, Hidenao Browse this author →KAKEN DB
Wakao, Hiroshi Browse this author →KAKEN DB
Keywords: Multiple sclerosis
Mucosal associated invariant T cells
Disease-modifying therapy
Issue Date: 5-Aug-2016
Publisher: Springer
Journal Title: Springerplus
Volume: 5
Start Page: 1259
Publisher DOI: 10.1186/s40064-016-2923-9
Abstract: Background: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination, gliosis and axonal loss in the Central Nervous System. Although the etiology of the disease has remained enigmatic, recent studies have suggested a role of the innate-like T cells, called Mucosal Associated Invariant T cells (MAITs) in the pathophysiology. In the present study, we have analyzed the relative frequency of MAITs and the expression of the cell surface antigens in MAITs to seek a possible link to the disease. Results: There was little difference in the frequency of total MAITs between healthy donors (HDs) and untreated MS patients, whereas the latter harbored more CD8lo/neg (DN) MAITs concomitant with a decrease in CD8high MAITs and in CD4 MAITs compared with those in HDs. While the expression of CCR5, CCR6, CD95, CD127, and CD150 has increased in untreated subjects compared with that in HDs, CD45RO has declined in untreated subjects in both DN MAITs and CD8hi MAITs. FTY720 therapy has increased the relative frequency of total MAITs in a time-dependent fashion up to 2 years. Intriguingly, FTY720 therapy for 3 years reversed the above phenotype, engendering more CD8high MAITs accompanied with decreased DN MAITs. FTY720 therapy affected the cytokine production from CD4 T cells and also enhanced the relative frequency of cells producing both TNF-α and IFN-γ from MAITs, CD8 T cells, and CD4 T cells compared with that in untreated subjects. Conclusions: FTY 720 therapy enhanced the relative frequency of MAITs in MS patients in a time-dependent manner. Although the expression of CD8 in MAITs has been affected early by FTY720, longer treatment has reversed the phenotypic change. These data demonstrated that FTY720 induced dynamic change in the relative frequency and in the phenotype of MAITs in MS.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 若尾 宏

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