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The dynamics of mucosal-associated invariant T cells in multiple sclerosis


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タイトル: The dynamics of mucosal-associated invariant T cells in multiple sclerosis
著者: Sugimoto, Chie 著作を一覧する
Hirotani, Makoto 著作を一覧する
Yoshikiyo, Kazunori 著作を一覧する
Koshimizu, Uichi 著作を一覧する
Wakao, Rika 著作を一覧する
Horinouchi, Takahiro 著作を一覧する
Mazaki, Yuichi 著作を一覧する
Higashi, Tsunehiko 著作を一覧する
Fukazawa, Toshiyuki 著作を一覧する
Fujita, Hiroyoshi 著作を一覧する
Sasaki, Hidenao 著作を一覧する
Wakao, Hiroshi 著作を一覧する
キーワード: Multiple sclerosis
Mucosal associated invariant T cells
Disease-modifying therapy
発行日: 2016年 8月 5日
出版者: Springer
誌名: Springerplus
巻: 5
開始ページ: 1259
出版社 DOI: 10.1186/s40064-016-2923-9
抄録: Background: Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination, gliosis and axonal loss in the Central Nervous System. Although the etiology of the disease has remained enigmatic, recent studies have suggested a role of the innate-like T cells, called Mucosal Associated Invariant T cells (MAITs) in the pathophysiology. In the present study, we have analyzed the relative frequency of MAITs and the expression of the cell surface antigens in MAITs to seek a possible link to the disease. Results: There was little difference in the frequency of total MAITs between healthy donors (HDs) and untreated MS patients, whereas the latter harbored more CD8lo/neg (DN) MAITs concomitant with a decrease in CD8high MAITs and in CD4 MAITs compared with those in HDs. While the expression of CCR5, CCR6, CD95, CD127, and CD150 has increased in untreated subjects compared with that in HDs, CD45RO has declined in untreated subjects in both DN MAITs and CD8hi MAITs. FTY720 therapy has increased the relative frequency of total MAITs in a time-dependent fashion up to 2 years. Intriguingly, FTY720 therapy for 3 years reversed the above phenotype, engendering more CD8high MAITs accompanied with decreased DN MAITs. FTY720 therapy affected the cytokine production from CD4 T cells and also enhanced the relative frequency of cells producing both TNF-α and IFN-γ from MAITs, CD8 T cells, and CD4 T cells compared with that in untreated subjects. Conclusions: FTY 720 therapy enhanced the relative frequency of MAITs in MS patients in a time-dependent manner. Although the expression of CD8 in MAITs has been affected early by FTY720, longer treatment has reversed the phenotypic change. These data demonstrated that FTY720 induced dynamic change in the relative frequency and in the phenotype of MAITs in MS.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 若尾 宏


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