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Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer

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Title: Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer
Authors: Kitao, Tomoka Browse this author
Hirata, Kenji Browse this author →KAKEN DB
Shima, Katsumi Browse this author
Hayashi, Takashi Browse this author
Sekizawa, Mitsunori Browse this author
Takei, Toshiki Browse this author
Ichimura, Wataru Browse this author
Harada, Masao Browse this author
Kondo, Keishi Browse this author
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: Lung cancer
Metabolic tumor volume
Total lesion glycolysis
Issue Date: 2-Aug-2016
Publisher: BioMed Central
Journal Title: BMC cancer
Volume: 16
Start Page: 576
Publisher DOI: 10.1186/s12885-016-2624-3
Abstract: Background: Volume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response in nonsmall cell lung cancer (NSCLC). We aimed to examine intra- and inter-operator reproducibility to measure the MTV and TLG, and to estimate their dependency on the uptake time. Methods: Fifty NSCLC patients underwent preoperative FDG-PET. After an injection of FDG, the whole body was scanned twice: at the early phase (61.4 ± 2.8 min) and delayed phase (117.7 ± 1.6 min). Two operators independently defined the tumor boundary using three different delineation methods: (1) the absolute SUV threshold method (MTVp and TLGp; p = 2.0, 2.5, 3.0, 3.5), (2) the fixed% SUVmax threshold method (MTVq% and TLGq%; q = 35, 40, 45), and (3) the adaptive region-growing method (MTVARG and TLGARG). Parameters were compared between operators and between phases. Results: Both the intra- and inter-operator reproducibility were high for all parameters using any method (intra-class correlation > 0.99 each). MTV3.0 and MTV3.5 resulted in a significant increase from the early to delayed phase (P < 0.05 for both), whereas MTV2.0 and MTV2.5 neither increased nor decreased (P = n.s.). All of the MTVq% values significantly decreased over time (P < 0.01), whereas MTVARG and TLG with any delineation method increased significantly (P < 0.05). Conclusions: High reproducibility of MTV and TLG was obtained by all of the methods used. MTV2.0 and MTV2.5 were the least sensitive to uptake time, and may be good alternatives when we compare images acquired with different uptake times, although applying constant uptake time is important for volume measurement.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 健司

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