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Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer


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タイトル: Reproducibility and uptake time dependency of volume-based parameters on FDG-PET for lung cancer
著者: Kitao, Tomoka 著作を一覧する
Hirata, Kenji 著作を一覧する
Shima, Katsumi 著作を一覧する
Hayashi, Takashi 著作を一覧する
Sekizawa, Mitsunori 著作を一覧する
Takei, Toshiki 著作を一覧する
Ichimura, Wataru 著作を一覧する
Harada, Masao 著作を一覧する
Kondo, Keishi 著作を一覧する
Tamaki, Nagara 著作を一覧する
キーワード: Lung cancer
Metabolic tumor volume
Total lesion glycolysis
発行日: 2016年 8月 2日
出版者: BioMed Central
誌名: BMC cancer
巻: 16
開始ページ: 576
出版社 DOI: 10.1186/s12885-016-2624-3
抄録: Background: Volume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response in nonsmall cell lung cancer (NSCLC). We aimed to examine intra- and inter-operator reproducibility to measure the MTV and TLG, and to estimate their dependency on the uptake time. Methods: Fifty NSCLC patients underwent preoperative FDG-PET. After an injection of FDG, the whole body was scanned twice: at the early phase (61.4 ± 2.8 min) and delayed phase (117.7 ± 1.6 min). Two operators independently defined the tumor boundary using three different delineation methods: (1) the absolute SUV threshold method (MTVp and TLGp; p = 2.0, 2.5, 3.0, 3.5), (2) the fixed% SUVmax threshold method (MTVq% and TLGq%; q = 35, 40, 45), and (3) the adaptive region-growing method (MTVARG and TLGARG). Parameters were compared between operators and between phases. Results: Both the intra- and inter-operator reproducibility were high for all parameters using any method (intra-class correlation > 0.99 each). MTV3.0 and MTV3.5 resulted in a significant increase from the early to delayed phase (P < 0.05 for both), whereas MTV2.0 and MTV2.5 neither increased nor decreased (P = n.s.). All of the MTVq% values significantly decreased over time (P < 0.01), whereas MTVARG and TLG with any delineation method increased significantly (P < 0.05). Conclusions: High reproducibility of MTV and TLG was obtained by all of the methods used. MTV2.0 and MTV2.5 were the least sensitive to uptake time, and may be good alternatives when we compare images acquired with different uptake times, although applying constant uptake time is important for volume measurement.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 平田 健司


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