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Fluorescence lifetime measurements in heterogeneous scattering medium


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タイトル: Fluorescence lifetime measurements in heterogeneous scattering medium
著者: Nishimura, Goro 著作を一覧する
Awasthi, Kamlesh 著作を一覧する
Furukawa, Daisuke 著作を一覧する
キーワード: radiative transfer equation
fluorescence lifetime
time-resolved method
発行日: 2016年 7月
出版者: Society of Photo-Optical Instrumentation Engineers (SPIE)
誌名: Journal of biomedical optics
巻: 21
号: 7
開始ページ: 075013
出版社 DOI: 10.1117/1.JBO.21.7.075013
抄録: Fluorescence lifetime in heterogeneous multiple light scattering systems is analyzed by an algorithm without solving the diffusion or radiative transfer equations. The algorithm assumes that the optical properties of medium are constant in the excitation and emission wavelength regions. If the assumption is correct and the fluorophore is a single species, the fluorescence lifetime can be determined by a set of measurements of temporal point-spread function of the excitation light and fluorescence at two different concentrations of the fluorophore. This method is not dependent on the heterogeneity of the optical properties of the medium as well as the geometry of the excitation-detection on an arbitrary shape of the sample. The algorithm was validated by an indocyanine green fluorescence in phantom measurements and demonstrated by an in vivo measurement.
Rights: © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. ”Fluorescence lifetime measurements in heterogeneous scattering medium,” J. Biomed. Opt. 21(7), 075013 (2016)
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 西村 吾朗


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