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Female mice avoid male odor from the same strain via the vomeronasal system in an estrogen-dependent manner

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Title: Female mice avoid male odor from the same strain via the vomeronasal system in an estrogen-dependent manner
Authors: Yano, Saori Browse this author
Sakamoto, Kentaro Q. Browse this author →KAKEN DB
Habara, Yoshiaki Browse this author →KAKEN DB
Keywords: accessory olfactory bulb
inbreeding avoidance
Issue Date: Nov-2015
Publisher: Oxford University Press
Journal Title: Chemical Senses
Volume: 40
Issue: 9
Start Page: 641
End Page: 648
Publisher DOI: 10.1093/chemse/bjv052
PMID: 26377346
Abstract: Inbreeding avoidance is essential to providing offspring with genetic diversity. Females' mate choice is more crucial than males' for successful reproduction because of the high cost of producing gametes and limited chances to mate. However, the mechanism of female inbreeding avoidance is still unclear. To elucidate the mechanism underlying inbreeding avoidance by females, we conducted Y-maze behavioral assays using BALB/c and C57BL/6 female mice. In both strains, the avoidance of male urine from the same strain was lower in the low estrogen phase than in the high estrogen phase. The estrous cycle-dependent avoidance was completely prevented by vomeronasal organ (VNO) removal. To assess the regulation of the vomeronasal system by estrogen, the neural excitability was evaluated by immunohistochemistry of the immediate early gene products. Although estrogen did not affect neural excitability in the VNO, estrogen enhanced the neural excitability of the mitral cell layer in the AOB induced by urine from the cognate males. These results suggest that female mice avoid odor from genetically similar males in an estrogen-dependent manner via the vomeronasal system and the excitability of the mitral cells in the AOB is presumed to be regulated by estrogen.
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Chemical Senses following peer review. The definitive publisher-authenticated version Chem. Senses (2015) 40 (9): 641-648 is available online at:
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 葉原 芳昭

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